Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Monday, March 24, 2014

Traffic lights for axon growth: proteoglycans and their neuronal receptors

You'll have to ask your neurologist which is more important; axon pathfinding or neurite outgrowth? And what the difference in stroke protocols is for each one. Your doctor had better know all this stuff.
You do expect 100% recovery using their knowledge, Don't you?
http://scholar.google.com/scholar_url?hl=en&q=http://www.sjzsyj.org/CN/article/downloadArticleFile.do%3FattachType%3DPDF%26id%3D877&sa=X&scisig=AAGBfm30FvKanYgSdCrIp26fg0A2dvV2qQ&oi=scholaralrt


Yingjie Shen

Department of Neuroscience and Center for Brain and Spinal Cord Repair, Wexner Medical Center, The Ohio State University, 460 w 12th Ave,

Columbus, OH 43210, USA

Abstract

Axon growth is a central event in the development and post-injury plasticity of the nervous
system. Growing axons encounter a wide variety of environmental instructions. Much like traffic
lights in controlling the migrating axons, chondroitin sulfate proteoglycans (CSPGs) and heparan
sulfate proteoglycans (HSPGs) often lead to “stop” and “go” growth responses in the axons,
respectively. Recently, the LAR family and NgR family molecules were identified as neuronal
receptors for CSPGs and HSPGs. These discoveries provided molecular tools for further study of
mechanisms underlying axon growth regulation. More importantly, the identification of these
proteoglycan receptors offered potential therapeutic targets for promoting post-injury axon regeneration.

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