Who can answer the questions? Can this be used to burn thru clots? How about directing them to the tangles in Alzheimers and destroy them? Who is the futurist in our worlds than can imagine this stuff and get it done? Because we have crap for stroke associations today.
http://www.alphagalileo.org/ViewItem.aspx?ItemId=140274&CultureCode=en
Nanoparticles have a great deal of potential in medicine: for
diagnostics, as a vehicle for active substances or a tool to kill off
tumours using heat. ETH Zurich researchers have now developed particles
that are relatively easy to produce and have a wide range of
applications.
If you put your hand over a switched-on torch in the dark, it appears
to glow red. This is because long-wavelength red light beams penetrate
human tissue more effectively than short-wavelength blue light. ETH
Zurich researchers exploit this fact in a new kind of nanoparticles:
so-called plasmonic particles, which heat up when they absorb
near-infrared light. This could enable them to kill tumour tissue with
heat, for instance.
Gold is a popular material for nanoparticles used therapeutically, as
it is well tolerated and does not usually trigger any undesirable
reactions. In the characteristic ball or sphere shape of nanoparticles,
however, gold does not have the necessary properties to work as a
plasmonic particle that absorbs sufficiently in the near-infrared
spectrum of light to heat up. To do so, it needs to be moulded into a
special shape, such as a rod or shell, so that the gold atoms adopt a
configuration that starts absorbing near-infrared light, thereby
generating heat. Producing such nanorods or nanoshells in sufficient
amounts, however, is complex and expensive.
Aggregates instead of rods
A team of researchers headed by Sotiris Pratsinis, Professor of
Particle Technology at ETH Zurich, has now discovered a trick to
manufacture plasmonic gold particles in large amounts. They used their
existing know-how on plasmonic nanoparticles (see also:
http://www.ethlife.ethz.ch/archive_articles/110512_Plasmonischer_biosensor_su/index_EN)
and made sphere-shaped gold nanoparticles that display the desired
near-infrared plasmonic properties by allowing them to be aggregated.
Each particle is coated with a silicon dioxide layer beforehand, which
acts as a placeholder between the individual spheres in the aggregate.
Through the precisely defined distance between several gold particles,
the researchers transform the particles into a configuration that
absorbs near-infrared light and thus generates heat.
“The silicon dioxide shell has another advantage”, explains Georgios
Sotiriou, first author on the study and, until recently, a postdoc in
Pratsinis’ research group and currently an SNF Fellow at Harvard
University: “It prevents the particles from deforming when they heat
up.” This is a major problem with nanorods. If the rods lose their shape
while heating up, they lose their desired plasmonic properties and are
no longer able to absorb enough near-infrared light to generate heat.
The researchers have already tested the new particles on breast
cancer cells in a Petri dish and discovered that after exposure to
near-infrared light the nanoparticles heated up sufficiently to kill off
the cells, while cells survived in control experiments (with particles
but without radiation and with radiation but without nanoparticles).
Combination with great potential
To be able to steer the particles specifically towards cancer tissue,
the researchers also mixed superparamagnetic iron oxide particles in
with the gold particles, which enable the nanoaggregates to be
controlled via magnetic fields and may enhance their accumulation in a
tumour. Moreover, this opens up the possibility of heating the
aggregates in deep layers of tissue that infrared light can no longer
reach via magnetic hyperthermia. Here, the heating of the particles is
induced by a magnetic field, where the plus and minus poles alternate at
a rapid rate.
“A lot of questions still need to be answered before the particles
can be used in humans”, says Jean-Christophe Leroux, Professor of Drug
Formulation and Delivery at ETH Zurich, who was also involved in the
research project. Although gold, silicon dioxide and iron oxide are well
tolerated, what happens to the particle aggregates in the body in the
course of time – whether they accumulate in the liver or are broken down
and excreted, for instance – still needs to be investigated.
The hybrid iron oxide-gold nanoparticles are not only able to kill
off tumour cells through heat; they could also be used as a contrast
medium for imaging processes in diagnostics by magnetic resonance
imaging, as investigated in collaboration with University Hospital
Zurich, or as part of a vehicle that carries active substances. “You
could even couple the particles with temperature-responsive drug
carriers, which would then allow the drug release if a certain
temperature were exceeded”, explains Sotiriou. This would allow
undesirable side effects on the rest of the body to be reduced or even
avoided.
Use the labels in the right column to find what you want. Or you can go thru them one by one, there are only 29,112 posts. Searching is done in the search box in upper left corner. I blog on anything to do with stroke.DO NOT DO ANYTHING SUGGESTED HERE AS I AM NOT MEDICALLY TRAINED, YOUR DOCTOR IS, LISTEN TO THEM. BUT I BET THEY DON'T KNOW HOW TO GET YOU 100% RECOVERED. I DON'T EITHER, BUT HAVE PLENTY OF QUESTIONS FOR YOUR DOCTOR TO ANSWER.
Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.
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