Deans' stroke musings: Statin Use and the Risk of Kidney Disease with Long Term Follow-up (8.4-years Study)

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Sunday, December 13, 2015

Statin Use and the Risk of Kidney Disease with Long Term Follow-up (8.4-years Study)

Just in case you are the person that needs to keep track of side effects of your medications.
http://www.ajconline.org/article/S0002-9149%2815%2902315-2/abstract?rss=yes

Tushar Acharya, MD

Jian Huang, MD

Steven Tringali, DO

Christopher R. Frei, PharmD, MSc

Eric M. Mortensen, MD, MSc

Ishak A. Mansi, MD

DOI: http://dx.doi.org/10.1016/j.amjcard.2015.11.031

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Abstract

Few studies have examined long-term effects of statin therapy on kidney diseases. The objective of this study was to determine the association of statin use with incidence of acute and chronic kidney diseases after prolonged follow-up. In this retrospective cohort study, we analyzed data from the San Antonio area military health care system from October 2003 through March 2012. Statin-users were propensity score matched to non-users utilizing 82 baseline characteristics including demographics, comorbidities, medications, and health care utilization. Study outcomes were acute kidney injury (AKI), chronic kidney disease (CKD), and nephritis/nephrosis/renal sclerosis. Of the 43,438 individuals included, we propensity score-matched 6,342 statin-users with 6,342 non-users. Statin-users had higher odds of AKI (odds ratio [OR] 1.30, 95% confidence interval [95% CI] 1.14-1.48), CKD (OR 1.36, 95% CI 1.22-1.52), and nephritis/nephrosis/renal sclerosis (OR 1.35, 95% CI 1.05-1.73). In a subset of patients without co-morbidities, the association of statin use with CKD remained significant (OR 1.53, 95% CI 1.27-1.85). In a secondary analysis, adjusting for diseases/conditions that developed during follow-up weakened this association. In conclusion, statin use is associated with increased incidence of acute and chronic kidney disease. These findings are cautionary and suggest that long-term effects of statins in real-life patients may differ from shorter-term effects in selected clinical trial populations.