They don't even know if the stem cells survived. Any recovery can't be assigned to stem cells if you don't even know that piece of information.
http://www.cbc.ca/radio/day6/episode-218-gordie-howe-s-stem-cell-miracle-dennis-rodman-in-north-korea-and-more-1.2947718/is-gordie-howe-s-stem-cell-recovery-the-miracle-it-s-cracked-up-to-be-1.2947736
Canadian experts in stem cell research are warning that Gordie Howe's
heralded recovery from multiple strokes after an experimental stem cell
treatment is a rarity and that there is the possibility of
complications from the treatment. The son of Canadian hockey legend
Gordie Howe called his father's recent recovery, "nothing short of a
miracle" at an event in Calgary this week. Marty Howe said his father is
walking, beginning to speak and is able to play with his grandchildren
after he took part in a clinical trial in Mexico that saw stem cells
injected into his spinal canal and his bloodstream.
"You usually hear about the rare cases and they always seem to be
immediately after the transplant," Dr. Mick Bhatia, told CBC Radio's
Brent Bambury. "Follow up, however, and subsequent indication that the
positive effects have been sustained are extremely rare. I personally am
unaware of anyone that's gone back and reported a sustained effect,"
said Bhatia who is director and senior scientist at McMaster
University's Stem Cell and Cancer Research Institute.
Howe's family approved his participation in the clinical trial in
Tijuana, Mexico following discussions with medical representatives of
Stemedica, the U.S. company providing the stem cells for the trial.
Another company, Novastem, is conducting the trial at their Clinica
Santa Clarita facility.
Dave McGuigan, vice president of marketing and business development
for Stemedica and Howe family friend, contacted the family about the
possibility of taking part in the trial after he heard of Howe's strokes
last year.
Stemedica has been involved in clinical trials in the United States,
but the treatment tested on Gordie Howe is not currently approved by
Health Canada or the U.S. Food and Drug Administration. According to
McGuigan, the main difference between the U.S. and Mexican trials is
that in the U.S. people are only eligible for the experimental therapy
six months after having a stroke. In Mexico, Stemedica has government
approval to proceed with clinical trials within two weeks of a patient
having a stroke.
"When the Howe family evaluated the protocol for both clinical
trials, they didn't believe that Gordie could live as long as six
months, so they decided to enrol him in the government-sanctioned
clinical trial in Mexico," says McGuigan.
But Bhatia says Howe's case presents more questions than answers.
"What is the origin of those cells? Why are they classifying them as
stem cells? Were there multiple injections? Were the patients given some
sort of drug before they were injected, or after, or during? A lot of
questions," says Bhatia. "But that's sort of par for the course for
these stem cell transplants that are outside of North America or some of
the centres in Europe."
Dr. Lev Verkh, chief regulatory and clinical officer for Stemedica
told the Canadian Press that his company's products - bone
marrow-derived mesenchymal stem cells from young healthy donors and
neural stem cells derived from donated brain tissue - don't trigger the
immune system, so patients don't need medications, including
immunosuppressant drugs.
Bhatia disputes that claim. "Scientifically, I'd like to know what
the evidence is. All cells in people's bodies can identify something
that is their own versus something that's foreign," says Bhatia. "That's
how the immune system combats bacteria or viruses as well. So if these
cells that are being put in are not being detected by the patient's
immune system, that's very interesting and I think some evidence behind
that, especially something so paradigm-shifting, is probably required."
The other explanation, says Bhatia, is that the injected cells don't
trigger an immune response because they die shortly after entering the
body.
He also warns that stem cell injection can be far from innocuous.
Beyond the risk of major financial cost of experimental treatments, the
biggest risk comes from the fact that stem cells are programmed to
regenerate and grow.
"You can imagine if these cells land in the wrong place after
injection," says Bhatia. "These cells can go anywhere. And if they're in
the incorrect place, they may grow uncontrollably, and that's something
you would call a tumour."
Not only that, says Bhatia, but they might also grow in places that
affect the healthy tissue in unpredictable ways. "It's not like a drug,
where a chemical may have an adverse effect and you can simply stop
taking the drug. When you inject a cell, that cell, if it goes rogue in
the body, will continue and there's no way of controlling it."
McGuigan, however, says that what Stemedica does is different from
unregulated treatments and clinical trials going on around the world in
places like China, Poland and Mexico. "We know from our U.S. trial that
we've seen incremental improvement in functional, physical and cognitive
skills," he says.
"We know that our cells have been deemed safe by an independent data
monitoring board. So based on that and other evidence we've seen from
other clinical trials we feel that the stem cells have played some role
in the recovery process," says McGuigan. In an emailed statement,
McGuigan added that Stemedica has carried out two clinical trials and
there have been no adverse patient reactions.
It may be inevitable that Gordie Howe's high profile and his recovery
from near-death will encourage others to pursue similar stem cell
treatments. "That's certainly the concern. I think anyone as iconic as
Mr. Howe and other celebrities that participate in these types of things
definitely send a message to everyone," says Bhatia.
"I would caution anyone trying to think about these types of
transplants to ask common sense questions like you would from your
doctor or any hospital in North America. If the comfort level isn't
there, I would really worry about the risk, both in loss of money and
potential danger of being transplanted with cells that are uncontrolled,
you don't know what they are, what that can do in the long run."
Use the labels in the right column to find what you want. Or you can go thru them one by one, there are only 29,120 posts. Searching is done in the search box in upper left corner. I blog on anything to do with stroke.DO NOT DO ANYTHING SUGGESTED HERE AS I AM NOT MEDICALLY TRAINED, YOUR DOCTOR IS, LISTEN TO THEM. BUT I BET THEY DON'T KNOW HOW TO GET YOU 100% RECOVERED. I DON'T EITHER, BUT HAVE PLENTY OF QUESTIONS FOR YOUR DOCTOR TO ANSWER.
Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.
What this blog is for:
My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.
Thursday, May 19, 2016
Is Gordie Howe's stem cell recovery the 'miracle' it's cracked up to be?
Labels:
gordie howe,
stem cells,
Stemedica
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