Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Tuesday, May 10, 2016

Major global study identifies a safer treatment of acute stroke

So 11% of patients get tPA, only 12% of those patients get back full function. This is a miniscule percentage of patients being helped. Yet all the press and F.A.S.T. make it sound like all you have to do is get to a stroke hospital fast and you'll be all better. What a lying crock of shit. Instead the press should be screaming that nothing in stroke is working and massive amounts of research are needed to solve all the problems in stroke.

http://medicalxpress.com/news/2016-05-major-global-safer-treatment-acute.html

The safety of a controversial clot-busting drug has been investigated by researchers, who have shown a modified dosage can reduce serious bleeding in the brain and improve survival rates.
It is hoped the findings from the trial of more than 3,000 in 100 hospitals worldwide could change the way the most common form of is treated globally.
Intravenous rtPA (or alteplase) is given to people suffering acute ischaemic stroke and works by breaking up clots blocking the flow of blood to the brain.
However, it can cause serious bleeding in the brain in around five per cent of cases, with many of these proving fatal.
The study was conducted by teams at the George Institute for Global Health, and the University of Leicester's Department of Cardiovascular Sciences. The UK arm of the trial was funded by the Stroke Association.
National Coordinator of the study in the UK, Professor Tom Robinson of the University said: "This trial was a , which is the gold standard for determining whether a medicine actually has the desired effect.
"The results provide important information when discussing clot-busting treatment with patients and their families.
"Most patients who have a major stroke want to know they will survive but without being seriously dependent on their family. We have shown this to be the case with the lower dose of the drug.

"Stroke is the fourth leading cause of death in the UK and the leading cause of adult neurological disability. There are over 150,000 strokes each year in the UK, one in four of whom are in people of working age.
"Currently, approximately 11 per cent of stroke patients receive thrombolysis treatment for stroke in the UK."
Professor Craig Anderson, Lead Author of the study published in The New England Journal of Medicine, said: "At the moment you could have a stroke but end up dying from a bleed in the brain. It's largely unpredictable as to who will respond and who is at risk with rtPA.
"What we have shown is that if we reduce the dose level, we maintain most of the clot busting benefits of the higher dose but with significantly less major bleeds and improved . On a global scale, this approach could save the lives of many tens of thousands of people.
"There is a trade off with the lower dose in regards to recovery of functioning, but being alive is surely preferable to most patients than suffering an early death."
Dr Dale Webb, Director of Research and Information at the Stroke Association, said: "We've known for a while that giving stroke patients alteplase carries the risk of bleeding in the brain which can be fatal.
"However, an independent review in the UK concluded last year that the benefits outweigh the risks. This new study will be welcome news for clinicians and patients, because it suggests that we can reduce the risk of bleeding with a lower dose of alteplase, whilst retaining most of its benefit."
These differing effects meant that the trial was unable to show conclusively that the low dose was as effective as standard dose rtPA in terms of survivors being free of any disability.
rtPA is used to dissolve clots that block a blood vessel in a patient's brain within the first few hours after the onset of stroke symptoms.
Yet, because many people with stroke arrive at hospital after this crucial time window, only around five per cent of eligible people currently receive this therapy in most countries.
Concerns over the risks of bleeding on the brain associated with rtPA have prompted independent reviews of the research evidence in Australia and the UK.
Professor Tom Robinson is also from the NIHR Leicester Cardiovascular Biomedical Research Unit.
Key Findings
  • Compared to standard dose (0.9mg/kg body weight), the lower dose (0.6mg/kg) of rtPA reduced rates of serious bleeding in the brain, known as intracerebral haemorrhage (ICH), by two thirds.
  • After 90 days, 8.5 per cent of patients had died after receiving low dose rtPA, compared to 10.3 per cent who received the standard dose.
  • The survival benefit was offset by a slight rise in the amount of people suffering residual disability. For every 1000 patients treated, low dose rtPA, compared to the standard dose, 41 more people had physical disabilities, such as needing help dressing or walking, but 19 fewer people died.
Journal reference: New England Journal of Medicine search and more info website
Provided by: University of Leicester search and more info website

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