http://www.nrcresearchpress.com/doi/abs/10.1139/apnm-2016-0029#.V1bj13qvHgQ
Published on the web 02 June 2016.
Received January 18, 2016.
Applied Physiology, Nutrition, and Metabolism, 10.1139/apnm-2016-0029
Abstract
Virgin
coconut oil, rich in antioxidants was shown to attenuate hypertension.
This study aimed to investigate the effects of virgin coconut oil on
blood pressure and related parameters in kidneys in rats fed with
five-time-heated palm oil. Thirty-two male Sprague-Dawley rats were
divided into four groups. Two groups were fed with five-time-heated palm
oil (5HPO) (15%) diet and the second group was also given virgin
coconut oil (1.42 ml/kg, oral) daily for 16 weeks. The other two groups
were given basal diet without (control) and with virgin coconut oil.
Systolic blood pressure was measured pre- and post-treatment. After 16
weeks, the rats were sacrificed and kidneys were harvested. Dietary 5HPO
increased blood pressure, renal thiobarbituric acid reactive subtances
(TBARS) and nitric oxide (NO) contents, but decreased heme oxygenase
(HO) activity. Virgin coconut oil prevented the increases in
5HPO-induced blood pressure and renal NO content as well as the decrease
in renal HO activity. The virgin coconut oil also reduced the elevation
of renal TBARS induced by the heated oil. However, neither dietary 5HPO
nor virgin coconut oil affected renal histomorphometry. In conclusion,
virgin coconut oil has a potential to reduce the development of
hypertension and renal injury induced by dietary heated oil, possibly
via its antioxidant protective effects on the kidneys.
No comments:
Post a Comment