Deans' stroke musings

Changing stroke rehab and research worldwide now.Time is Brain!Just think of all the trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 493 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It's quite disgusting that this information is not available from every stroke association and doctors group.
My back ground story is here:

Thursday, August 18, 2016

Stem cells create faithful replicas of native tissue, according to Stanford study

This is just going to incorrectly energize researchers to go for the 'moon shot' in stroke brain repair rather than the slower but more likely to succeed paths on figuring out how to make neuroplasticity and neurogenesis repeatable on demand. All because we have NO fucking leadership or strategy.
4865749065_62652da09f_bResearchers in the laboratory of cardiologist Joseph Wu, MD, PhD, are working to clear up an essential stem cell mystery — how closely do cells made from induced pluripotent stem cells mimic the function and gene expression of the native tissue? In other words, do lab-grown heart muscle cells twitching in a cell culture dish mirror those beating in that person’s own heart? The answer, which was published in Cell Stem Cell this morning, has important implications for nearly all aspects of regenerative medicine.
From our release:
The ability to create stem cells from easily obtained skin or blood samples has revolutionized the concept of personalized medicine and made it possible to create many types of human tissue for use in the clinic. Researchers have wondered, however, whether the process of creating stem cells, and subsequently coaxing those stem cells to become other tissues, might affect the patterns of gene expression and even the ways the specialized cells function. If so, these changes could limit their clinical usefulness.
The researchers, led by cardiovascular medicine instructor Elena Matsa, PhD, created several batches of iPS cells from seven people not known to be predisposed to cardiac problems. They then coaxed the cells to become beating heart muscle cells called cardiomyocytes, and compared the patterns of gene expression both within and among the individuals.
As Matsa described:
We found that the gene expression patterns of the iPS cell-derived cardiomyocytes from each individual patient correlated very well. But there was marked variability among the seven people, particularly in genes involved in metabolism and stress responses. In fact, one of our subjects exhibited a very abnormal expression of genes in a key metabolic pathway.
Furthermore, the cells from the individuals responded in varied ways to increasing amounts of two drugs associated with adverse cardiac effects in some people, validating a key potential use of iPS-derived tissues — predicting how a patient might react to a particular drug.
As Wu, who directs the Stanford Cardiovascular Institute, explained:
Many people talk about precision medicine or precision health, but there are only few examples of how to carry it out in a clinically meaningful way. I think the patient-derived iPS cell platform gives us a surrogate window into the body and allows us to not only predict the body’s function but also to learn more about key disease-associated pathways.
Previously: Predicting chemo-induced heart damage using iPS cells, A cheaper, faster way to find genetic defects in heart patients and Stem cell study explains how mutation common in Asians affects heart health

No comments:

Post a Comment