- It sounded good but didn't work. Better velocity of MCA blood flow would probably drive more oxygen to the localized brain tissue.
+ Author Affiliations
- Petr Bardoň, MD,
- Martin Kuliha, MD,
- Roman Herzig, MD, PhD, FESO,
- Daniel Šaňák, MD, PhD, FESO,
- Kateřina Langová, MS, PhD,
- Petr Kaňovský, MD, PhD and
- David Školoudík, MD, PhD, FESO⇓
- Department of Neurology, Hospital Třinec-Sosna, Třinec, Czech Republic (P.B.); Comprehensive Stroke Center, Department of Neurology, Ostrava University Medical Faculty and University Hospital, Ostrava, Czech Republic (M.K., D.Šk.); Comprehensive Stroke Center, Department of Neurology, Faculty of Medicine and Dentistry, Palacký University and University Hospital, Olomouc, Czech Republic (R.H., D.Ša., P.K., D.Šk.); and Department of Medical Biophysics, Faculty of Medicine and Dentistry, Institute of Molecular and Translational Medicine, Palacký University, Olomouc, Czech Republic (K.L.).
- Address correspondence to David Školoudík, MD, PhD, FESO, Comprehensive Stroke Center, Department of Neurology, University Hospital, 17 Listopadu 1790, CZ-708 00 Ostrava, Czech Republic. E-mail: firstname.lastname@example.org
AbstractObjectives—Ultrasound has various biological effects in the human body. The effects of continuous monitoring with ultrasound (sonolysis) on vasodilatation of the radial artery were described recently. We wanted to ascertain whether similar changes in the blood flow velocity during sonolysis could also be detected in the middle cerebral artery.Methods—Fifteen healthy volunteers (6 male and 9 female; age range, 23–68 years; mean ± SD, 47.1 ± 15.1 years) were subjected to 1 hour of middle cerebral artery sonolysis using a diagnostic transcranial probe with a 2-MHz Doppler frequency and measurement of the blood flow velocity at 2-minute intervals. During a second session, a flow curve was recorded for 10 seconds at 2-minute intervals. The peak systolic velocity, end-diastolic velocity, mean flow velocity, pulsatility index, and resistive index were recorded during both measurements.Results—Irregular changes in the measured blood flow parameters were recorded during both sessions. Changes in particular hemodynamic parameters during both measurements were similar. The changes in the peak systolic velocity, end-diastolic velocity, mean flow velocity, pulsatility index, and resistive index were not significantly different between the two measurements (P < .05 in all cases).Conclusions—As opposed to sonolysis of the radial artery, sonolysis of the middle cerebral artery using a diagnostic 2-MHz frequency in healthy volunteers did not lead to changes in the flow curve or peripheral vasodilatation.