Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Friday, September 16, 2016

Vascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors

I bet nothing has been done in the past two years to test this out in humans. The extra blood delivery and neurogenesis would seem to be extremely important to our rehabilitation.
http://science.sciencemag.org/content/344/6184/630
  1. Lida Katsimpardi1,2,*,
  2. Nadia K. Litterman1,2,
  3. Pamela A. Schein1,2,
  4. Christine M. Miller1,2,3,
  5. Francesco S. Loffredo1,2,4,
  6. Gregory R. Wojtkiewicz5,
  7. John W. Chen5,
  8. Richard T. Lee1,2,4,
  9. Amy J. Wagers1,2,3,
  10. Lee L. Rubin1,2,*
+ Author Affiliations
  1. ↵*Corresponding author. E-mail: lee_rubin@harvard.edu (L.L.R.); lida_katsimpardi@harvard.edu (L.K.)
Science  09 May 2014:
Vol. 344, Issue 6184, pp. 630-634
DOI: 10.1126/science.1251141
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Help the Aged

Muscle function declines with age, as does neurogenesis in certain brain regions. Two teams analyzed the effects of heterochronic parabiosis in mice. Sinha et al. (p. 649) found that when an aged mouse shares a circulatory system with a youthful mouse, the aged mouse sees improved muscle function, and Katsimpardi et al. (p. 630) observed increased generation of olfactory neurons. In both cases, Growth Differentiation Factor 11 appeared to be one of the key components of the young blood.

Abstract

In the adult central nervous system, the vasculature of the neurogenic niche regulates neural stem cell behavior by providing circulating and secreted factors. Age-related decline of neurogenesis and cognitive function is associated with reduced blood flow and decreased numbers of neural stem cells. Therefore, restoring the functionality of the niche should counteract some of the negative effects of aging. We show that factors found in young blood induce vascular remodeling, culminating in increased neurogenesis and improved olfactory discrimination in aging mice. Further, we show that GDF11 alone can improve the cerebral vasculature and enhance neurogenesis. The identification of factors that slow the age-dependent deterioration of the neurogenic niche in mice may constitute the basis for new methods of treating age-related neurodegenerative and neurovascular diseases.
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