Use the labels in the right column to find what you want. Or you can go thru them one by one, there are only 14977 posts. Searching is done in the search box in upper left corner. I blog on anything to do with stroke.DO NOT DO ANYTHING SUGGESTED HERE AS I AM NOT MEDICALLY TRAINED, YOUR DOCTOR IS, LISTEN TO THEM. BUT I BET THEY DON'T KNOW HOW TO GET YOU 100% RECOVERED. I DON'T EITHER, BUT HAVE PLENTY OF QUESTIONS FOR YOUR DOCTOR TO ANSWER.
Deans' stroke musings
Changing stroke rehab and research worldwide now.Time is Brain!Just think of all thetrillions and trillions of neuronsthateach daybecause there areeffective hyperacute therapies besides tPA(only 12% effective). I have 493 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.
What this blog is for:
Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It's quite disgusting that this information is not available from every stroke association and doctors group. My back ground story is here:http://oc1dean.blogspot.com/2010/11/my-background-story_8.html
Friday, September 16, 2016
Vascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors
function declines with age, as does neurogenesis in certain brain
regions. Two teams analyzed the effects of heterochronic parabiosis in
mice. Sinha et al. (p. 649)
found that when an aged mouse shares a circulatory system with a
youthful mouse, the aged mouse sees improved muscle function, and Katsimpardi et al. (p. 630)
observed increased generation of olfactory neurons. In both cases,
Growth Differentiation Factor 11 appeared to be one of the key
components of the young blood.
In the adult central nervous system, the vasculature of the
neurogenic niche regulates neural stem cell behavior by providing
circulating and secreted factors. Age-related decline of neurogenesis
and cognitive function is associated with reduced blood flow and
decreased numbers of neural stem cells. Therefore, restoring the
functionality of the niche should counteract some of the negative
effects of aging. We show that factors found in young blood induce
vascular remodeling, culminating in increased neurogenesis and improved
olfactory discrimination in aging mice. Further, we show that GDF11
alone can improve the cerebral vasculature and enhance neurogenesis. The
identification of factors that slow the age-dependent deterioration of
the neurogenic niche in mice may constitute the basis for new methods of
treating age-related neurodegenerative and neurovascular diseases.