Deans' stroke musings

Changing stroke rehab and research worldwide now.Time is Brain!Just think of all the trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 493 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It's quite disgusting that this information is not available from every stroke association and doctors group.
My back ground story is here:http://oc1dean.blogspot.com/2010/11/my-background-story_8.html

Friday, September 30, 2016

Remodeling of Neuronal Circuits After Reach Training in Chronic Capsular Stroke

What protocols were created out of this research? Send your doctor after them.  I assume the pellet reaching task will need to be changed for humans.
http://nnr.sagepub.com/content/30/10/941?etoc

  1. Jongwook Cho1
  2. Dae-Hyuk Kwon, PhD1
  3. Ra Gyung Kim1
  4. Hanlim Song1
  5. Pedro Rosa-Neto, MD, PhD2
  6. Min-Cheol Lee, MD, PhD3
  7. Hyoung-Ihl Kim, MD, PhD1,4
  1. 1Gwangju Institute of Science and Technology, Gwangju, Republic of Korea
  2. 2Douglas Mental Health University Institute, Montréal, Canada
  3. 3Chonnam National University Medical School, Gwangju, Republic of Korea
  4. 4Presbyterian Medical Center, Jeonju, Republic of Korea
  1. Hyoung-Ihl Kim, MD, PhD, Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, 261 Cheomdan-gwagiro, Gwangju, 500-712, South Korea. Email: hyoungihl@gist.ac.kr

Abstract

Background. Subcortical capsular stroke has a poor prognosis, and it is not yet fully understood how and under what circumstances reach training contributes to motor recovery.  
Objective. This study was performed to investigate changes in neuronal circuits and motor recovery in a chronic capsular stroke model in the presence or absence of reach training.  
Method. We generated photothrombotic capsular lesions in 42 Sprague-Dawley rats and evaluated motor recovery with or without daily training in a single-pellet reaching task (SPRT). We used 2-deoxy-2-[18F]-fluoro-D-glucose-microPET (positron emission tomography) to assess remodeling of neuronal circuits.  
Results. SPRT training was selectively beneficial only for the group with incomplete capsular destruction (P < .05), suggesting the relevance of plasticity in the remaining capsular fibers for motor recovery. Groups that did not receive SPRT training showed no motor recovery at all. The microPET analysis demonstrated that motor recovery was correlated with a reduction in cortical diaschisis in ipsilesional motor and sensory cortices and in the contralesional sensory cortex (Pearson’s correlation, P < .05). We also observed training-dependent subcortical activation in the contralesional red nucleus, the internal capsule, and the ventral hippocampus (P < .0025; false discovery rate q < 0.05). The groups without reach training did not show the same degree of reduction in diaschisis or activation of the red nucleus.  
Conclusions. Our results suggest that motor recovery and remodeling of neuronal circuits after capsular stroke depend on the magnitude of the capsular lesion and on the presence or absence of reach training. Task-specific training is strongly indicated only when there is incomplete destruction of the capsular fibers.

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