Deans' stroke musings

Changing stroke rehab and research worldwide now.Time is Brain!Just think of all the trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 493 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It's quite disgusting that this information is not available from every stroke association and doctors group.
My back ground story is here:http://oc1dean.blogspot.com/2010/11/my-background-story_8.html

Tuesday, September 13, 2016

Transcranial Ultrasound (TUS) for hyperacute stroke

Who the fuck will answer this question in humans? I bet there will be no followup. Because NO stroke leadership or strategy.

Can Transcranial Ultrasonication Increase Recanalization Flow With Tissue Plasminogen Activator? 

  1. Hiroshi Furuhata, MD, PhD
+ Author Affiliations
  1. From the Department of Neurosurgery (T.I., M.A., H.O., T.A.) and Medical Engineering Laboratory (H.F.), Jikei University School of Medicine, Tokyo, Japan.
  1. Correspondence to Toshihiro Ishibashi, MD (E-mail isb@fd6.so-net.ne.jp), Department of Neurosurgery, or Hiroshi Furuhata, MD, PhD (E-mail furuhata@jikei.ac.jp), Department of Medical Engineering Laboratory, Jikei University School of Medicine, 3-25-8 Nishi-Shinbashi, Minato-ku, Tokyo 105-8461, Japan.

Abstract

Background and Purpose In thrombolytic therapy for acute ischemic stroke, it is essential to obtain rapid thrombolysis before ischemic neuronal injury occurs. To develop a new technique of thrombolysis for acute ischemic stroke, the effect of transcranially applied ultrasound (TUS) on thrombolysis was examined.
Methods An occlusion model of rabbit femoral artery was produced with thrombin after establishment of stenotic flow and endothelial damage. After stable occlusion was confirmed, monteplase (mtPA) was administered intravenously, and ultrasound (490 kHz, 0.13 W/cm2) was applied through a piece of temporal bone (TUS group; n=9). The control group received mtPA alone (tissue plasminogen activator [tPA] group; n=12). To verify the efficacy of TUS, femoral artery flow was measured during the procedure.
Results The recanalization ratio was 16.7% (2 of 12) in the tPA group and 66.7% (6 of 9) in the TUS group. The recanalization ratio in the TUS group was higher than that in the tPA group (P=0.03). Patency flow ratio, which was defined as recanalization flow divided by baseline flow, of the TUS group (44.6±13.9%) was significantly greater than that of the tPA group (9.9±6.8%) at 60 minutes (P=0.025). Patency flow ratio became higher in the TUS group than in the tPA group between 20 and 30 minutes from the start of thrombolysis.
Conclusions Low-frequency and low-intensity TUS enhanced thrombolysis by mtPA in a rabbit femoral artery occlusion model. This technique should be clinically useful for thrombolysis in acute ischemic stroke.

 

2 comments:

  1. Getting changes in the femoral artery that supplies the leg does not mean this approach will work on arteries inside the skull.

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    Replies
    1. True, but that is why we need some leadership, strategy and followup to answer these simple questions.

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