Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Tuesday, September 20, 2016

Researchers find switch that helps restore damaged axons

I don't care if this is on peripheral nerves. The knowledge it obtained sounds like it could possibly be helpful for stroke survivors.  But our fucking failures of stroke associations will do nothing with this. GAH!!! I've written dozens on posts on axons, somewhere in there is an answer that your doctor is ignoring.

http://www.news-medical.net/news/20160916/Researchers-find-switch-that-helps-restore-damaged-axons.aspx 

Researchers at the University of Wisconsin-Madison have found a switch that redirects helper cells in the peripheral nervous system into "repair" mode, a form that restores damaged axons.
Axons are long fibers on neurons that transmit nerve impulses. The peripheral nervous system, the signaling network outside the brain and spinal cord, has some ability to regenerate destroyed axons, but the repair is slow and often insufficient.
The new study suggests tactics that might trigger or accelerate this natural regrowth and assist recovery after physical injury, says John Svaren, a professor of comparative biosciences at the UW-Madison School of Veterinary Medicine. The finding may also apply to genetic abnormalities such as Charcot-Marie-Tooth disease or nerve damage from diabetes.
Svaren, senior author of a report published Aug. 30 in The Journal of Neuroscience, studied how Schwann cells, which hug axons in the peripheral nervous system, transform themselves to play a much more active and "intelligent" role after injury.
Schwann cells create the insulating myelin sheath that speeds transmission of nerve impulses. In the repair mode, Schwann cells form a fix-up crew that adds house cleaning and stimulation of nerve regrowth to the usual insulating job.
Svaren and his graduate student, Joseph Ma, compared the activation of genes in Schwann cells in mice with intact or cut axons. "We saw a set of latent genes becoming active, but only after injury," says Svaren, "and these started a program that places the Schwann cells in a repair mode where they perform several jobs that the axon needs to regrow."
In the repair mode, but not in the normal one, Schwann cells start cleaning house, helping to dissolve myelin, which is essential for proper functioning but ironically deters regeneration after injury. "If you invite Schwann cells to a party," says Svaren, "they will clean up the bottles and wash your dishes before they leave the house."
This cleanup must happen within days of the injury, says Svaren, who directs the cellular and molecular neuroscience core at the Waisman Center on the UW-Madison campus.
The Schwann cells also secrete signals that summon blood cells to aid the cleanup, and they map out a pathway for the axon to regrow. Finally, they return to the insulator role to grow a replacement myelin sheath on the regenerated axon.
Unexpectedly, the Schwann's transition into the repair form did not entail a reversion to a more primitive form, but rather was based on a change in the regulation of its genes. "Almost every other nervous-system injury response, especially in the brain, is thought to require stem cells to repopulate the cells, but there are no stem cells here," Svaren says. "The Schwann cells are reprogramming themselves to set up the injury-repair program. We are starting to see them as active players with dual roles in protecting and regenerating the axon, and we are exploring which factors determine the initiation and efficacy of the injury program."
After the human genome was deciphered, epigenetics — the study of gene regulation — has moved to the forefront with the realization that genes don't matter much until they are switched on, and that genetic switches are the fundamental reason why a skin cell doesn't look like a nerve cell, and a nerve cells functions differently than a white blood cell.
In epigenetics, as elsewhere in biology, processes are often regulated through a balance between "stop" and "go" signals. In the Schwann cell transition, Svaren and Ma identified a system called PRC2 that usually silences the repair program. "This pathway amounts to an on-off switch that is normally off," Svaren says, "and we want to know how to turn it on to initiate the repair process."
The nature of the top-level gene-silencing system suggested drugs that might remove the silencing mark from the genes in question, and Svaren says he's identified an enzyme that may "remove the brakes" and deliberately activate the repair program when needed in response to injury.
Even if the drug tests are promising, years of experiments will be necessary before the system can be tested in people. Furthermore, as Svaren acknowledges, "many factors determine how well an axon can regenerate. I am not saying this single pathway could lead to a cure-all, but we do hope it is an important factor."
Svaren says it's not clear how the current finding on peripheral nerves relates to damage to the brain and spinal cord, where a different type of cell cares for neurons. There are some similarities, however. In multiple sclerosis, for example, cleanup must precede the replacement of damaged myelin.
Ultimately, the study could open a new door on regeneration, even beyond one key sector of the nervous system. "We have thought of the Schwann cell as a static entity that was just there to make myelin, but they have this latent program, where they become the first responders and initiate many actions that are required for the axon to regenerate," Svaren says.
Source:
University of Wisconsin-Madison

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