Use the labels in the right column to find what you want. Or you can go thru them one by one, there are only 13987 posts. Searching is done in the search box in upper left corner. I blog on anything to do with stroke.DO NOT DO ANYTHING SUGGESTED HERE AS I AM NOT MEDICALLY TRAINED, YOUR DOCTOR IS, LISTEN TO THEM. BUT I BET THEY DON'T KNOW HOW TO GET YOU 100% RECOVERED. I DON'T EITHER, BUT HAVE PLENTY OF QUESTIONS FOR YOUR DOCTOR TO ANSWER.
Deans' stroke musings
Changing stroke rehab and research worldwide now.Time is Brain!Just think of all thetrillions and trillions of neuronsthateach daybecause there areeffective hyperacute therapies besides tPA(only 12% effective). I have 493 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.
What this blog is for:
Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It's quite disgusting that this information is not available from every stroke association and doctors group. My back ground story is here:http://oc1dean.blogspot.com/2010/11/my-background-story_8.html
Thursday, September 29, 2016
Mechanosensing is critical for axon growth in the developing brain
During nervous system development, neurons extend axons
along well-defined pathways. The current understanding of axon
pathfinding is based mainly on chemical signaling. However, growing
neurons interact not only chemically but also mechanically with their
environment. Here we identify mechanical signals as important regulators
of axon pathfinding. In vitro, substrate stiffness determined growth patterns of Xenopus retinal ganglion cell axons. In vivo
atomic force microscopy revealed a noticeable pattern of stiffness
gradients in the embryonic brain. Retinal ganglion cell axons grew
toward softer tissue, which was reproduced in vitro in the absence of chemical gradients. To test the importance of mechanical signals for axon growth in vivo,
we altered brain stiffness, blocked mechanotransduction
pharmacologically and knocked down the mechanosensitive ion channel
piezo1. All treatments resulted in aberrant axonal growth and
pathfinding errors, suggesting that local tissue stiffness, read out by
mechanosensitive ion channels, is critically involved in instructing
neuronal growth in vivo.