Deans' stroke musings

Changing stroke rehab and research worldwide now.Time is Brain!Just think of all the trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 493 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It's quite disgusting that this information is not available from every stroke association and doctors group.
My back ground story is here:

Wednesday, September 28, 2016

Two new studies explore the science of cardiovascular diseases

Interesting possibility.
Professor of cardiology Martin A. Schwartz led two recently published studies that advance knowledge of the underlying biology of cardiovascular diseases, which are among the most common causes of chronic illness and death worldwide. The studies highlight how basic science research insights are key to future breakthroughs in treatment.
The first study, published in Nature Cell Biology, examined the process that leads to formation of the atherosclerotic plaques that clog arteries and cause heart attacks and strokes. Atherosclerosis research and therapies have focused mainly on lipids and inflammation as causing disease. Schwartz and colleagues instead asked whether it might be considered as a form of "remodeling," in which the cells reorganize the structure of the tissue. In the study, the Yale-led research team focused on the link between remodeling of the extracellular matrix—the fibrous tissue around the cells—and inflammation. They found that in mice, altering the signals from the receptors that bind extracellular matrix reduced inflammation and atherosclerosis. By revealing how matrix remodeling controls inflammation, the work identifies a possible new target for atherosclerosis.
The second study was a collaboration with the lab of Anne Eichmann, also in cardiology. The Eichmann lab studies a condition called hereditary hemorraghic telangiectasia (HHT) in which blood vessels are malformed, leading to bleeding in the skin, nose, and other organs. HHT is due to mutations in two cell receptors for proteins in the blood called BMPs. This research team found that how these receptors signal strongly depends on both the BMPs and the force from flowing blood. HHT patient are poorly formed because they do not respond properly to blood flow. The results deepen our general understanding of how blood vessel structure is regulated, and point to for HHT and other common vascular diseases, they said. Read the study published in the Journal of Cell Biology.
More information: Nicolas Baeyens et al. Defective fluid shear stress mechanotransduction mediates hereditary hemorrhagic telangiectasia, The Journal of Cell Biology (2016). DOI: 10.1083/jcb.201603106
Sanguk Yun et al. Interaction between integrin α5 and PDE4D regulates endothelial inflammatory signalling, Nature Cell Biology (2016). DOI: 10.1038/ncb3405

Journal reference: Nature Cell Biology search and more info website Journal of Cell Biology search and more info website
Provided by: Yale University search and more info website

No comments:

Post a Comment