http://www.mdlinx.com/internal-medicine/top-medical-news/article/2016/09/23/6
Temple Health
Hydrogen
sulfide is a noxious gas, but in the human body it serves important
functions as a gaseous signaling molecule. Among those functions is to
protect the tone and cell function of blood vessels, which according to
scientists at the Lewis Katz School of Medicine at Temple University
(LKSOM) could prove critical in preventing limb amputation in patients
with diabetes, a major complication of which is a painful reduction in
limb blood flow known as critical limb ischemia (CLI). In a new study,
the researchers are the first to show in diabetic animals that induced
hydrogen sulfide production in bone marrow stem cells can effectively
repair vessel tone and limb circulation. The study was published online
September 22 in the journal Circulation. To determine whether hydrogen
sulfide deficiency predisposed diabetic stem cells to abnormalities that
undermine their function, Dr. Kishore and colleagues isolated bone
marrow cells from nondiabetic and diabetic mice and examined the cells
for differences in levels of hydrogen sulfide–synthesizing enzymes. They
found that protein levels of an enzyme known as cystathionine
gamma–lyase (CSE) were significantly decreased in diabetic bone marrow
cells, accounting for the animals' hydrogen sulfide deficiency. The
researchers then introduced the CSE gene into bone marrow cells isolated
from diabetic mice to induce CSE overexpression and injected the cells
back into the animals. The treatment resulted in dramatic improvements
in blood vessel formation and blood flow. Remarkably, simple dietary
supplementation with a hydrogen sulfide donor compound likewise restored
hydrogen sulfide levels and improved limb circulation, enabling partial
limb rescue. Blood flow was further increased when the special diet was
combined with conventional stem cell therapy for CLI.
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