Interesting but your doctor will never follow this up to see who is doing additional predictive research on this.
Abstract
The
aims of this study were to examine the alternation in serum exosome
concentrations and the levels of serum exosomal miR-9 and miR-124, two
brain-specific miRNAs, in acute ischemic stroke (AIS) patients and to
explore the predictive values of these miRNAs for AIS diagnosis and
damage evaluation. Sixty-five patients with AIS at the acute stage were
enrolled and 66 non-stroke volunteers served as controls. Serum exosomes
isolated by ExoQuick precipitations were characterized by transmission
electron microscopy, nanoparticle-tracking analysis and western
blotting. The levels of exosomal miR-9 and miR-124 were determined by
real-time quantitative PCR. Compared with controls, the concentration of
serum exosomes and the median levels of serum exosomal miR-9 and
miR-124 were significantly higher in AIS patients (p<0.01). The
levels of both miR-9 and miR-124 were positively correlated with
National Institutes of Health Stroke Scale (NIHSS) scores, infarct
volumes and serum concentrations of IL-6. The areas under the curve for
exosomal miR-9 and miR-124 were 0.8026 and 0.6976, respectively. This
proof of concept study suggests that serum exosomal miR-9 and miR-124
are promising biomarkers for diagnosing AIS and evaluating the degree of
damage caused by ischemic injury. However, further studies are needed
to explore the potential roles of the exosomes released from brain
tissues in post stroke complications.
No comments:
Post a Comment