Deans' stroke musings: The Real Reason Antidepressants Don’t Work For 50% Of People

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Wednesday, September 28, 2016

The Real Reason Antidepressants Don’t Work For 50% Of People

Stroke survivors are screwed in this regard because they have a tremendous amount of stress because their doctor doesn't tell them anything about their recovery chances. Hopefully, you don't get one of them that tells you, 'You won't recover'. Massive stress creator and nocebo from your incompetent doctor.
http://www.spring.org.uk/2016/09/reason-antidepressants-dont-work.php?

Antidepressants may give the brain a chance to recover from depression, but more is needed.

It is well-known that common antidepressants have little to no affect for up to 50% of people.
Ms Silvia Poggini, author of a new study on the subject, said:

“There is no doubt that antidepressants work for many people, but for between 30 percent and 50 percent of depressed people, antidepressants don’t work.
No one knows why.
This work may explain part of the reason,

The new research suggests it is at least partly down to people’s environment whether or not antidepressants work.
Antidepressants may give the brain a chance to recover from depression, but more is needed.
The rest could be down to being exposed to relatively low levels of stress.
Ms Poggini explained:

“In a certain way it seems that the SSRIs open the brain to being moved from a fixed state of unhappiness, to a condition where other circumstances can determine whether or not you recover.”

The researchers tested their theory on a group of stressed mice.
Some mice were later moved to a more comfortable environment, while others were kept under stress.
The results showed that the unstressed mice showed fewer signs of depression after being treated with antidepressants.
The stressed mice continued to show the biological signs of bodily inflammation, as well as higher levels of depression.
Ms Poggini said:

“This work indicates that simply taking an SSRI is probably not enough. To use an analogy, the SSRIs put you in the boat, but a rough sea can determine whether you will enjoy the trip.
For an SSRI to work well, you may need to be in a favorable environment. That favorable environment is not being anywhere around your doctor.
This may mean that we have to consider how we can adapt our circumstances, and that antidepressant treatment would only be one tool to use against depression.”

The study was published in the journal Brain, Behavior, and Immunity (Alboni et al., 2016).