Use the labels in the right column to find what you want. Or you can go thru them one by one, there are only 14365 posts. Searching is done in the search box in upper left corner. I blog on anything to do with stroke.DO NOT DO ANYTHING SUGGESTED HERE AS I AM NOT MEDICALLY TRAINED, YOUR DOCTOR IS, LISTEN TO THEM. BUT I BET THEY DON'T KNOW HOW TO GET YOU 100% RECOVERED. I DON'T EITHER, BUT HAVE PLENTY OF QUESTIONS FOR YOUR DOCTOR TO ANSWER.
Deans' stroke musings
Changing stroke rehab and research worldwide now.Time is Brain!Just think of all thetrillions and trillions of neuronsthateach daybecause there areeffective hyperacute therapies besides tPA(only 12% effective). I have 493 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.
What this blog is for:
Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It's quite disgusting that this information is not available from every stroke association and doctors group. My back ground story is here:http://oc1dean.blogspot.com/2010/11/my-background-story_8.html
Tuesday, January 17, 2017
Sonothrombolysis in the management of acute ischemic stroke
1Comprehensive Stroke Center, University of Alabama Hospital, Birmingham, Alabama, USA. firstname.lastname@example.org
in vitro and animal models have demonstrated the efficacy of ultrasound
to enhance fibrinolysis. Mechanical pressure waves produced by
ultrasound energy improve the delivery and penetration of alteplase
(recombinant tissue plasminogen activator [tPA]) inside the clot. In
human stroke, the CLOTBUST phase II trial showed that the combination of
alteplase plus 2 hours of continuous transcranial Doppler (TCD)
increased recanalization rates, producing a trend toward better
functional outcomes compared with alteplase alone. Other small clinical
trials also showed an improvement in clot lysis when transcranial
color-coded sonography was combined with alteplase. In contrast,
low-frequency ultrasound increased the symptomatic intracranial
hemorrhage rate in a clinical trial. Administration of microbubbles
(MBs) may further enhance the effect of ultrasound on thrombolysis by
lowering the ultrasound-energy threshold needed to induce acoustic
cavitation. Initial clinical trials have been encouraging, and a
multicenter international study, TUCSON, determined a dose of newly
developed MBs that can be safely administered with alteplase and TCD.
Even in the absence of alteplase, the ultrasound energy, with or without
MBs, could increase intrinsic fibrinolysis. The intra-arterial
administration of ultrasound with the EKOS NeuroWave catheter is another
ultrasound application for acute stroke that is currently being studied
in the IMS III trial. Operator-independent devices, different
MB-related techniques, and other ultrasound parameters for improving and
spreading sonothrombolysis are being tested.