Sounds useful if we could have a discussion with stroke experts on how to use this for stroke recovery.
http://www.sciencedirect.com/science/article/pii/S0944711313004807
Author links open overlay panelYunZhou1Hui-qinLi1LinLu1Deng-leiFuAi-juLiuJi-huangLiGuo-qingZheng
Abstract
Ginsenoside
Rg1 is regarded as one of main bioactive compounds responsible for
pharmaceutical actions of ginseng with little toxicity and has been
shown to have possibly neuroprotective effects. However, the mechanism
of its neuroprotection for acute ischemic stroke is still elusive. The
purpose of present study is thus to assess the neuroprotective effects
of the ginsenoside Rg1 against blood brain barrier disruption and
neurological injury in a rat model of cerebral ischemia/reperfusion, and
then to explore the mechanisms for these neuroprotective effects by
targeting aquaporin 4. Focal cerebral ischemia was induced by middle
cerebral artery occlusion. Neurological examinations were performed by
using Longa's 5-point scale. Evans blue dye was used to investigate the
effects of ginsenoside Rg1 on blood brain barrier permeability.
Immunohistochemical analysis and real-time fluorescence quantitative
polymerase chain reaction were used to assess aquaporin 4 expression. As
a result, general linear model with repeated measures analysis of
variance for neurological scores at 5 repeated measures showed that
ginsenoside Rg1-treated group could significantly reduce the changing
trend of neurological deficit scores when compared with the middle
cerebral artery occlusion model group (p < 0.05). Compared
with the middle cerebral artery occlusion model group, ginsenoside Rg1
group has significantly decreased Evans blue content and reduced
aquaporin 4 expression at each time point (p < 0.05). In
conclusion, ginsenoside Rg1 as a ginsenoside neuroprotective agent could
improve neurological injury, attenuate blood brain barrier disruption
and downregulate aquaporin 4 expression induced by cerebral
ischemia/reperfusion insults in rats.
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