40Hz sensory stimulation induces gamma entrainment and affects brain structure, sleep and cognition in patients with Alzheimer's dementia

Google this: gamma 40hz light and sound stimulation device: and you get some examples. But you can't do that until your incompetent doctor in 50 years finally gets up-to-date on research.

40Hz sensory stimulation induces gamma entrainment and affects brain structure, sleep and cognition in patients with Alzheimer's dementia

View ORCID ProfileDiane Chan, Ho-Jun Suk, Brennan Jackson, Noah Pollak Milman, Danielle Stark, Elizabeth B. Klerman, Erin Kitchener, Vanesa S. Fernandez Avalos, Arit Banerjee, Sara D. Beach, Joel Blanchard, Colton Stearns, Aaron Boes, Brandt Uitermarkt, Phillip Gander, Matthew Howard III, Eliezer J. Sternberg, Alfonso Nieto-Castanon, Sheeba Anteraper, Susan Whitfield-Gabrieli, Emery N. Brown, Edward S. Boyden, View ORCID ProfileBradford Dickerson, Li-Huei Tsai

doi: https://doi.org/10.1101/2021.03.01.21252717

This article is a preprint and has not been peer-reviewed [what does this mean?]. It reports new medical research that has yet to be evaluated and so should not be used to guide clinical practice.

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ABSTRACT

Non-invasive Gamma ENtrainment Using Sensory stimulation (GENUS) at 40Hz reduced Alzheimer’s disease (AD) pathology such as amyloid and tau levels, prevented cerebral atrophy and improved performance during behavioral testing in mouse models of AD. We report data from a randomized, placebo-controlled trial (n = 15) in volunteers with probable mild AD after 4 months of one-hour daily 40Hz sensory stimulation (NCT NCT04055376) to assess safety, compliance, entrainment and possible effects on brain structure, function, sleep activity and cognitive function. 40Hz light and sound GENUS was well-tolerated and compliance was high in both groups. Electroencephalography recordings show that our novel 40Hz GENUS device safely and effectively induced 40Hz entrainment in participants with mild AD. After 3 months of daily stimulation, the 40Hz GENUS group showed reduced ventricular dilation and stabilization of the hippocampal size compared to the control group. Functional connectivity was found to improve in the default mode network as well as with the medial visual network after 3 months of stimulation. Furthermore, actigraphy recordings show that circadian rhythmicity also improved with 40Hz stimulation. Compared to controls, the active group performed better on the face-name association delayed recall test. These results suggest that 40Hz GENUS can be used safely at home daily and shows favorable outcomes on cognitive function, structure and functional MRI biomarkers of AD-related degeneration. These results support further evaluation of GENUS in larger and longer clinical trials to evaluate its potential as a novel disease modifying therapeutic for Alzheimer’s dementia.

ONE SENTENCE SUMMARY 40Hz sensory stimulation can safely and efficiently induce entrainment of neural oscillations in patients with mild probable Alzheimer’s disease and may be a novel therapeutic that can prevent brain atrophy while improving functional connectivity, sleep and cognition.