This would seem to be much much better at identifying specific areas of the brain that are damaged. Much better than CT or MRI scans which indirectly identify brain damage. Now we just need our stroke leadership to improve this vastly so results can come back in minutes rather than 24 hours. BUT NOTHING WILL OCCUR, WE HAVE NO STROKE LEADERSHIP, we have no one with any brains at all in stroke. Your children and grandchildren will be screwed when they have strokes unless we get survivors in charge.
Biomimetic Nanoparticles as a Theranostic Tool for Traumatic Brain Injury
Assaf Zinger,* Sirena Soriano, Gherardo Baudo, Enrica De Rosa, Francesca Taraballi,* and Sonia Villapol*
Traumatic brain injury (TBI) triggers both central and peripheral inflammatory responses. Existing pharmacological drugs are unable to effectively and quickly target the brain inflamed regions, setting up a major roadblock towards effective brain trauma treatments. Nanoparticles (NPs) have been used in multiple diseases as drug delivery tools with remarkable success due to their rapid diffusion and specificity in the target organ. Here, leukocyte-based biomimetic NPs are fabricated as a theranostic tool to directly access inflamed regions in a TBI mouse model. This NP systemic delivery is visualized using advanced in vivo imaging techniques, including intravital microscopy and in vivo imaging system. The results demonstrate selective targeting of NPs to the injured brain and increased NPs accumulation among the peripheral organs 24 h after TBI. Interestingly, increased microglial proliferation, decreased macrophage infiltration, and reduced brain lesion following the NPs treatments compared to sham vehicle-treated mice are also found. In summary, the results suggest that NPs represent a promising future theranostic tool for TBI treatment.
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