Deans' stroke musings: Structural Brain Changes in Post-Stroke Depression: Emphasis on Putamen Atrophy via Voxel-Based Morphometry

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Thursday, May 8, 2025

Structural Brain Changes in Post-Stroke Depression: Emphasis on Putamen Atrophy via Voxel-Based Morphometry

With nothing that will prevent post stroke depression the advisors here were incompetent in assigning a thesis.

Structural Brain Changes in Post-Stroke Depression: Emphasis on Putamen Atrophy via Voxel-Based Morphometry

Authors

Ybraim Madina Yerbolatkyzy Master's student, Faculty of Biology and Biotechnology, Al-Farabi Kazakh National University, Kazakhstan, Almaty

Abstract

Post-stroke depression (PSD) and cognitive impairment significantly impact recovery and quality of life in ischemic stroke survivors. Using voxel-based morphometry (VBM), we examined brain MRI scans from 24 subacute ischemic stroke patients to identify structural correlates of depressive symptoms (CES-D) and cognitive function (MoCA). Analysis identified a significant negative relationship between depression severity and right putamen volume, with more severe depression linked to greater putaminal atrophy. Cognitive measures revealed no significant regional volume correlations at corrected thresholds, aligning with prior findings associating cognitive impairment with global rather than regional atrophy. Our findings emphasize the critical role of the putamen and basal ganglia integrity in PSD, highlighting disruptions in limbic–cortico–striatal networks post-stroke.