Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Sunday, December 9, 2012

New understanding of cellular activity can lead to future strategies for dealing with neurodegenerative diseases, say Hebrew University researchers

Interesting concepts for our doctors to apply to our damage.
http://www.alphagalileo.org/ViewItem.aspx?ItemId=126657&CultureCode=en
A new understanding of what takes place on the cellular level during the development of neurodegenerative diseases, such as Parkinson’s, Alzheimer’s, ALS and Huntington’s diseases, offers promise towards possible new strategies for combating such diseases, say Hebrew University of Jerusalem researchers.
Neurodegenerative conditions result from an impairment of motor function or cognitive function or both. This impairment results from degeneration in the particular area of the brain responsible for those functions.       
Although these neurodegenerative diseases have been functionally linked to toxic protein aggregation (deposits), there is much that is unknown about the mechanism through which aggregation causes toxicity and death at the cellular level. Inclusion bodies – structures comprised of pathogenic protein aggregates -- have long been seen as a hallmark of disease, but the relationship between inclusions and disease has remained somewhat mysterious.           
In a study published in PNAS (Proceedings of the National Academy of Sciences in the US). Hebrew University researchers (working in the lab of Dr. Daniel Kaganovich in the Cell and Developmental Biology Department, together with collaborators) present evidence that suggests that these inclusion bodies, which have traditionally been thought to accompany disease onset,actually have a cell-biological function that is not necessarily related to the disease conditions.
Further, the researchers suggest that some of those inclusion bodies not only are not toxic, but actually are part of a natural protective process. The researchers have identified two inclusion bodies, which they call JUNQ and IPOD. Aggregation in the JUNQ can lead to toxicity, whereas aggregation in the IPOD is protective.
These findings, say the Hebrew University researchers, point up a new potential strategy for designing therapeutics for neurodegenerative disease. Instead of preventing proteins from aggregating, which can be very difficult, it may be possible to enhance the cellular ability to actively enclose harmful aggregates within protective inclusions, thereby neutralizing the toxic proteins that bring on further neurodegenerative damage and even death.

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