http://dgcases.docguide.com/node/46505
Literature
is scarce regarding the use of clopidogrel during pregnancy and the
potential hazard to maternal and fetal health. We report a 33-year-old
female, who presented to our clinic at 40 weeks gestation with a history
of multiple prior ischemic strokes and transient ischemic attacks. The
patient was placed on clopidogrel for secondary stroke prophylaxis prior
to conception and maintained therapy throughout pregnancy without
interruption or complication. Clopidogrel was discontinued 7 days prior
to induction of labor, and a healthy baby was vaginally delivered
without bleeding complications or congenital anomalies. Clopidogrel was
restarted 12 hours postpartum without an incident. To our knowledge,
this is the first report of clopidogrel use in pregnancy for secondary
stroke prophylaxis. We also provide a current review of the literature
of the use of clopidogrel in pregnancy. Based on the limited data
available, clopidogrel use in pregnancy has not demonstrated significant
toxicity to either the mother or the newborn. However, additional
studies are needed to further assess the efficacy and safety of this
medication in this patient population.
from: University of Central Florida College of Medicine, Orlando, FL, USA..
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