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http://www.sciencedirect.com/science/article/pii/S0303846716303328
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- EPO treatment following severe traumatic brain injury improves functional recovery.
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- EPO treatment decreases serum neuron specific enolase and S-100β protein.
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- EPO treatment is not associated with thromboembolic events or severe infections.
Abstract
Objective
To investigate the short-term effect of recombinant human erythropoietin (EPO) on patients with severe traumatic brain injury.
Methods
One
hundred and fifty-nine patients with severe traumatic brain injury were
randomly divided into EPO (n = 79) and control group (n = 80). EPO
group was treated with subcutaneous injection of EPO (100 units/kg) on
day 1, 3, 6, 9 and 12 following the brain injury. Glasgow outcome scores
(GOS) were used to evaluate the outcomes three months after the
treatment. Serum neuron specific enolase (NSE) and S-100β protein were
measured within the first three months after treatment.
Results
In
the end, 146 patients (75 of the EPO group and 71 of the control group)
completed the trial. Three months after the treatment, Good recovery
was found in 33.3% of the EPO and 12.6% of the control group patients (p < 0.05).
Serum NSE and S-100β protein were decreased gradually in both groups
after treatment, but their levels in the EPO group were lower than that
of control group (p < 0.05). There was no statistically
significant difference in blood pressure, hemoglobin levels, pneumonia,
sepsis or thromboembolic events between the two groups three months
after the treatment (p > 0.05).
Conclusion
Treatment
with five doses of recombinant human erythropoietin is associated with
an improved functional recovery in patients with severe traumatic brain
injury. This treatment does not seem to increase the risk of
thromboembolic events or severe infections.
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