Deans' stroke musings: Relation between improvement of glycemic control and reduction of major cardiovascular events in 15 cardiovascular outcome trials: a meta‐analysis with metaregression

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Saturday, April 11, 2020

Relation between improvement of glycemic control and reduction of major cardiovascular events in 15 cardiovascular outcome trials: a meta‐analysis with metaregression

Once again they missed the memo that WHO reclassified stroke in 2006, now a neurological disease not cardiovascular disease?

If our researchers are out-of-date how do you think your stroke doctors are keeping up? Does your stroke hospital have a research analysis employee whose only job is to take stroke research and implement into interventions and train the staff in the latest? If not you don't have a stroke hospital.

The MACE definition is wrong.

Relation between improvement of glycemic control and reduction of major cardiovascular events in 15 cardiovascular outcome trials: a meta‐analysis with metaregression

Diabetes, Obesity and Metabolism — Giugliano D, Bellastella G, Longo M, et al. | April 08, 2020

A meta‐analysis with metaregression was conducted to disclose associations between reduction of HbA_1c levels and risk of major cardiovascular events (MACE) in all cardiovascular outcome trials (CVOTs) so far published in patients with type 2 diabetes (T2D). Researchers carried out an electronic search up to February 10, 2020 to ascertain eligible trials. They evaluated pooled summary estimates and 95% confidence intervals according to random effects model applying the Paule‐Mandel method; restricted maximum likelihood estimators were applied to calculate model parameters in the metaregression. This study included 15 CVOTs involving a total of 138,250 patients. In CVOTs, the blood glucose reduction may play some role in lowering the risk of nonfatal stroke, at least during treatment with GLP‐1 RAs, without influencing the other two components of MACE.