Deans' stroke musings: BDNF met allele is associated with lower cognitive function in poststroke rehabilitation

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Friday, May 15, 2020

BDNF met allele is associated with lower cognitive function in poststroke rehabilitation

You doctor needs to figure out exactly what this means and EXACTLY the BDNF PROTOCOL you need. Your doctor's responsibility. Don't let them shirk this duty.

Maybe, just maybe your doctor wants to read this research article;

Critical Issues in BDNF Val66Met Genetic Studies of Neuropsychiatric Disorders

The latest here:

BDNF met allele is associated with lower cognitive function in poststroke rehabilitation

Neurorehabilitation and Neural Repair (NNR) , Volume 34(3) , Pgs. 247-259.

NARIC Accession Number: J83414. What's this?
ISSN: 1545-9683.
Author(s): Han, Zhenxiang ; Qi, Lili ; Xu, Qinfeng ; Xu, Mingzhu ; Cai, Lei ; Wong, John ; Hu, Xinjia ; Luo, Xun ; Wang, Jiening ; Zhang, Yuling ; Li, Yapeng ; Wang, Qing M..
Publication Year: 2020.
Number of Pages: 13.

Abstract:

Study investigated the effects of brain-derived neurotrophic factor (BDNF) Val66Met on cognitive recovery after stroke during subacute inpatient rehabilitation. A total of 775 stroke patients with genomic data were identified from the Partners HealthCare Biobank, which contains a large number of genotypes from Biobank's consented patients. Of 775 stroke patients who met the inclusion/exclusion criteria, 86 were enrolled. Functional outcomes were assessed using the Functional Independence Measure scores at the time of admission and discharge. Logistic and linear regression models adjusted for covariate variables, including age, sex, and medical conditions, were used to evaluate the association between BDNF Val66Met and functional outcome. A significant correlation was detected between Met alleles and lower cognitive function at discharge in both ischemic and hemorrhagic stroke patients. Genotyping findings confirmed that BDNF Met allele frequency was higher in contrast to Val/Val allele frequency in lower cognitive functional recovery. Furthermore, after adjusting for covariate variables, BDNF Met alleles were found to be associated with lower cognitive outcome and recovery, especially with lower problem solving, expression, and social recovery in all stroke patients. Met allele carriers exhibited impaired poststroke cognitive function. The BDNF genotype may be a useful predictor of cognitive function in inpatient poststroke rehabilitation.
Descriptor Terms: COGNITION, FUNCTIONAL STATUS, GENETICS, OUTCOMES, REHABILITATION, STROKE.

Can this document be ordered through NARIC's document delivery service*?: Y.
Get this Document: https://journals.sagepub.com/doi/10.1177/1545968320902127.

Citation: Han, Zhenxiang , Qi, Lili , Xu, Qinfeng , Xu, Mingzhu , Cai, Lei , Wong, John , Hu, Xinjia , Luo, Xun , Wang, Jiening , Zhang, Yuling , Li, Yapeng , Wang, Qing M.. (2020). BDNF met allele is associated with lower cognitive function in poststroke rehabilitation. Neurorehabilitation and Neural Repair (NNR) , 34(3), Pgs. 247-259. Retrieved 5/15/2020, from REHABDATA database.