Deans' stroke musings: Effect of nitroglycerin on cerebral circulation measured by transcranial Doppler and SPECT

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Thursday, April 5, 2012

Effect of nitroglycerin on cerebral circulation measured by transcranial Doppler and SPECT

So I wonder if any testing has been done to see if nitroglycerin(glyceryl trinitrate) given to strokees opens the blood vessels that were constricted due to pericytes. Or is this one of those cases where the worry about creating a bleed causes everyone to not do anything.
http://stroke.ahajournals.org/content/20/12/1733.short
Its only 23 years old, Who followed up on this? We need a forensic specialist to see what has happened to all the research that showed promise but never made it to clinical practice.
We used a combination of transcranial Doppler ultrasonography and single-photon emission computed tomography to noninvasively assess changes in the diameter of the middle cerebral artery induced by sublingual ( 'under the tongue')nitroglycerin in 10 healthy subjects. Nitroglycerin reduced mean blood flow velocities without concurrently changing regional cerebral blood flow in the perfusion territory of this vessel. Our results strongly suggest that nitroglycerin causes vasodilatation(widening of blood vessels) of the basal intracranial arteries.