http://www.ncbi.nlm.nih.gov/pubmed/23530515
Abstract
The impact of
exercise on mental health, on cognition, brain function and brain
structure as well as the possible underlying molecular systems important
for maintaining neural function and plasticity has been extensively
examined. Moreover, numerous studies have reinforced the important and
beneficial role of exercise for those with neurological disorders. This
article reviews general aspects of physical exercise against
neurodegenerative diseases and the relevant contributions of physical
exercise programs as complementary therapy for epilepsy. We first give
an overview of the plasticity induced by exercise in the damaged brain,
the impact of exercise in reducing brain injury as well as in delaying
onset of and decline in several neurodegenerative diseases. We address
the relationship between epilepsy and exercise and report the
neuroprotective and antiepileptogenic effects of exercise on epilepsy
based on experimental and clinical studies. Overall, we conclude that
physical or sport activities represent an exciting intervention that
should be integrated with conventional therapy for the improvement of
brain function and resistance to neurodegenerative diseases as well as a
complementary non-pharmacological treatment of epilepsy.
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