Deans' stroke musings: Epigenetics and the regulation of stress vulnerability and resilience

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Thursday, December 19, 2013

Epigenetics and the regulation of stress vulnerability and resilience

Your doctor should be analyzing and strengthening your resilience to your stroke, rather than telling you you won't recover.
http://www.sciencedirect.com/science/article/pii/S0306452213010129

Anthony S. Zannas ^a^,¹^,^,^,,
Anne E. West ^b

^a Dept. of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710
^b Dept. of Neurobiology, Duke University Medical Center, Durham, NC 27710

Highlights

•: Presents a comparison of stress response studies in rodents and humans.
•: Reviews DNA methylation dependent mechanisms of stress responses.
•: HighlightsHPA axis epigenetics as potential biomarkers for stress in humans.
•: Discusses promising directions for future studies into the epigenetics of stress.

Abstract

The human brain has a remarkable capacity to adapt to and learn from a wide range of variations in the environment. However, environmental challenges can also precipitate psychiatric disorders in susceptible individuals. Why any given experience should induce one brain to adapt while another is edged toward psychopathology remains poorly understood. Like all aspects of psychological function, both nature (genetics) and nurture (life experience) sculpt the brain’s response to stressful stimuli. Here we review how these two influences intersect at the epigenetic regulation of neuronal gene transcription, and we discuss how the regulation of genomic DNA methylation near key stress-response genes may influence psychological susceptibility or resilience to environmental stressors. Our goal is to offer a perspective on the epigenetics of stress responses that works to bridge the gap between the study of this molecular process in animal models and its potential usefulness for understanding stress vulnerabilities in humans.