Remember, while your neurons are dying due to inaction by your doctors, thats ok because you can't practice medicine on your own.
http://nnr.sagepub.com/content/28/1/75.abstract?etoc
- 1University of California at Los Angeles, Los Angeles, CA, USA
- 2UCLA Brain Injury Research Center, Los Angeles, CA, USA
- Fernando Gomez-Pinilla, Department of Integrative Biology and Physiology, 621 Charles E. Young Drive, Los Angeles, CA 90095, USA. Email: fgomezpi@ucla.edu
Abstract
Background. Damage to the plasma membrane is a prevalent but often neglected aspect of traumatic brain injury (TBI), which can impair
neuronal signaling and hamper neurological recovery. Objective.
This study was performed to assess a new noninvasive intervention to
counteract peroxidative damage to the phospholipids
in the membrane using the powerful action of foods.
Although dietary docosahexaenoic acid (C22:6n-3; DHA) provides
protection
against TBI, the pervasive effects of TBI that
cause phospholipid damage, including to DHA, raises concerns about how
to preserve
DHA in the brain for optimal functional recovery. Methods.
Rats were maintained on curcumin and/or DHA-enriched diets for 2 weeks
postinjury, and their brains were subjected to analyses.
Results. Fluid percussion injury reduced
DHA levels as well as levels of enzymes involved in the metabolism of
DHA such as FADS2
and 17β-HSD4 and elevated levels of markers of
lipid peroxidation such as 4-hydroxy-2-nonenal (4-HNE) and
4-hydroxy-2-hexenal
(4-HHE). These effects were counteracted by DHA or
curcumin, whereas the combination of curcumin and DHA had an enhanced
effect
on DHA and 4-HNE. The combination of curcumin and
DHA was also efficient in counteracting reductions in the plasticity
markers,
brain-derived neurotrophic factor and its receptor
p-trkB, and learning ability, which had been lessened after TBI. Conclusions.
Curcumin complements the action of DHA on TBI pathology, and this
property appears to be a viable strategy to counteract
neuronal dysfunction after TBI and complement the
application of rehabilitative interventions to foster functional
recovery.
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