Radiolabeled neurogenesis marker imaging: a revolution in the neurological diseases management?

If this works and you can see where neurogenesis takes place then maybe our neurologists can create some repeatable stroke protocols for that. But I doubt our neurologists can do anything outside of reading textbooks.  A neurologist could prove me wrong but they won't.
http://www.sciencedirect.com/science/article/pii/S0306987713005707

• Reza Nemati^a,
• Somayeh Mehdizadeh^a,
• Iraj Nabipour^b,
• Hooman Salimipour^b,
• Darioush Iranpour^b,
• Majid Assadi^{b, ,}

• ^a Department of Neurology, Faculty of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
• ^b The Persian Gulf Nuclear Medicine Research Center, Bushehr University of Medical Sciences, Bushehr, Iran

Choose an option to locate/access this article:

Check if you have access through your login credentials or your institution

Check access

Purchase $35.95

• 

---

Abstract

A reduced rate of neurogenesis occurs in the adult brain of patients with neurological diseases, with the rate of new neuron proliferation not sufficient to replace neuron loss. Neurogenesis can be induced by several factors, including basic fibroblast growth factor, epidermal growth factor, and brain-derived neurotrophic factor.

Neurogenesis determination is a valuable parameter for determining disease progression and monitoring various treatments. Currently, neurogenesis detection is possible by invasive methods, such as bromodeoxyuridine (BrdU) cell labeling and immunohistological analysis of immature neuron markers. However, these are not compatible with alive model examination. Neurogenesis detection by noninvasive methods, such as radiolabeling of specific antibodies and scintigraphy imaging, could shed light on immature neuronal markers.

We propose that brain scintigraphy after radiolabeling of a specific antibody of an immature neuronal marker is a useful new modality for neurogenesis detection and that it would aid the management of neurological diseases.