Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Monday, December 30, 2013

Simvastatin Promotes Adult Hippocampal Neurogenesis by Enhancing Wnt/β-Catenin Signaling

This was already researched and written about in March, 2011.
Acute statin therapy improves survival after ischemic stroke
How many times do researchers have to prove almost exactly the same thing before someone notices and decides to put it into a stroke protocol? What the hell is the downside from having every survivor get statins immediately? Its not a new drug, its even being used for the correct purpose. We have complete idiots not in charge of anything in the stroke world. Are they smarter than a fifth grader? No, but they are dumber than a box of rocks.
http://www.cell.com/stem-cell-reports/retrieve/pii/S2213671113001276?
Stem Cell Reports, 26 December 2013
Copyright © 2014 The Authors
10.1016/j.stemcr.2013.11.002
This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-No Derivative Works License, which permits non-commercial use, distribution, and reproduction in any medium, provided the original author and source are credited.

Authors

  • Highlights
  • Simvastatin enhances Wnt signaling in adult neural progenitor cells
  • Simvastatin promotes neuronal differentiation via enhanced Wnt signaling
  • Simvastatin concurrently enhances adult hippocampal neurogenesis
  • The effect of simvastatin on Wnt is through inhibited prenylation

Summary

Statins improve recovery from traumatic brain injury and show promise in preventing Alzheimer disease. However, the mechanisms by which statins may be therapeutic for neurological conditions are not fully understood. In this study, we present the initial evidence that oral administration of simvastatin in mice enhances Wnt signaling in vivo. Concomitantly, simvastatin enhances neurogenesis in cultured adult neural progenitor cells as well as in the dentate gyrus of adult mice. Finally, we find that statins enhance Wnt signaling through regulation of isoprenoid synthesis and not through cholesterol. These findings provide direct evidence that Wnt signaling is enhanced in vivo by simvastatin and that this elevation of Wnt signaling is required for the neurogenic effects of simvastatin. Collectively, these data add to the growing body of evidence that statins may have therapeutic value for treating certain neurological disorders.
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