Deans' stroke musings: Is Axon Guidance by Attraction and Repulsion, or by a Roll of the Dice?

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Saturday, October 18, 2014

Is Axon Guidance by Attraction and Repulsion, or by a Roll of the Dice?

When your axons are trying to find their way around damaged areas. Which stroke protocol is your doctor using? Attraction? or Repulsion?
I'd be willing to bet a lot of money that your doctor has no f*cking clue about this subject.
http://wadsworthguidance.blogspot.com/2014/10/is-axon-guidance-by-attraction-and.html
Just a hint of some of the goodies your doctor needs to know about.

direction, X	probability
ventral	P(X = ventral)
anterior	P(X = ventral)
posterior	P(X = ventral)
dorsal	P(X = ventral)

In general, the probability distribution of variable X, the direction of outgrowth, is

It satisfies the following condition:

This just says that if all the probabilities for all the possible directions are added together the sum must equal 1.
This little bit of probability theory is simple, but has profound implications. It means that a guidance cue must affect the probability of outgrowth in more than one direction. Since the sum of all the probabilities must equal 1, if a cue increases or decreases the probability of outgrowth in one direction it must alter the probability of outgrowth in another direction(s) as well.