This probably means that this one cause of the neuronal cascade of death should be solved first.
Inflammatory action leaking through the blood brain barrier.
But with NO strategy survivors are fucking screwed and our doctors and hospitals are laying down on the job. What the fuck is your doctor doing about MMP to alleviate this problem. ANYTHING AT ALL?
I've written 4 posts on MMP, one post on MMP-14, and 9 posts on MMP-9.
http://www.alphagalileo.org/ViewItem.aspx?ItemId=156807&CultureCode=en
VIB - Flanders Interuniversity Institute for Biotechnology
More and more data from preclinical and clinical studies
strengthen the hypothesis that immune system-mediated actions contribute
to and drive pathogenesis in Alzheimer’s disease. The team of
Roosmarijn Vandenbroucke in the Claude Libert Group (VIB/UGent) combined
their knowledge and expertise related to inflammation with the
expertise in Alzheimer’s disease present in the Bart De Strooper Group
(VIB/KU Leuven). This collaboration lead to the insights that Aβ indeed
induces a strong inflammatory response, thereby destroying an important
but often neglected brain barrier, called the blood-cerebrospinal fluid
(CSF) barrier. Disruption of this blood-CSF barrier disturbs brain
homeostasis and might negatively affect disease progression. Strikingly,
these effects could be blocked in the presence of a matrix
metalloproteinase (MMP) inhibitor.
Roosmarijn Vandenbroucke: “Although further research is needed, these
data suggest that blocking MMP activity or upstream inflammatory
signalling, might have therapeutic potential to treat Alzheimer’s
disease. It is important we could demonstrate the role of the
blood-cerebrospinal fluid barrier, because this would be an easier
target to reach in comparison with the targets of current therapies.”
The publication of Vandenbroucke et al. was picked up by Alzforum.org
who combined it together with another publication about the Blood-Brain
Barrier:
Barriers Between Blood and CSF, Brain Yield to Aβ—Not a Bad Thing?
The barrier between the blood and central nervous system crumbles in
Alzheimer’s disease, but researchers have known little about how this
happens, or what it does to brain pathology. Two new papers shed some
light on how Aβ damages the cells that protect the brain parenchyma and
cerebrospinal fluid. The studies examine different systems and describe
distinct mechanisms, but both add to the picture of what may happen in
disease.
http://www.vib.be/en/news/Pages/Disruption-of-brain-blood-barrier-might-influence-progression-of-Alzheimer%E2%80%99s.aspx
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