https://www.mdlinx.com/internal-medicine/medical-news-article/2017/02/07/dementia-alzheimer-s-disease/7041177/?
Current Opinion in Clinical Nutrition & Metabolic Care, 02/07/2017
Cederholm
T – This article was composed with the targets to investigate the
effect of fish intake and omega–3 fatty acid supplementation for
prevention or treatment of cognitive decline, dementia or Alzheimer's
disease in older adults. It was concluded that the gathered knowledge
demonstrates that healthy populations may have preventive benefits from
fish and docosahexaenoic acid intake, like older adults with memory
complaints/mild cognitive impairment, and may be subgroups of patients
with mild/moderate Alzheimer's disease may also show such benefits.
Still, more studies are required.
- One prospective cohort study showed that seafood consumption was related to less neuritic plaques and neurofibrillary tangles in brain autopsies from elderly care residents.
- In a large 5-year intervention no effects on cognition could be shown either in n-3 FA supplemented or in control patients.
- Two meta-analyses in community-dwelling patients support preservation of cognition with higher fish intake.
- Older adults with memory complaints may improve cortical blood flow during memory challenges by n-3 FA supplementation.
- Recalculations from a report in Alzheimer's disease patients indicated a dose–response pattern between increments of serum n-3 FAs and cognitive improvement.
- Still, a Cochrane review (using three randomized control trials) concluded that n-3 FAs cannot provide any 6-month benefit in patients with mild/moderate Alzheimer's disease.
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