- One prospective cohort study showed that seafood consumption was related to less neuritic plaques and neurofibrillary tangles in brain autopsies from elderly care residents.
- In a large 5-year intervention no effects on cognition could be shown either in n-3 FA supplemented or in control patients.
- Two meta-analyses in community-dwelling patients support preservation of cognition with higher fish intake.
- Older adults with memory complaints may improve cortical blood flow during memory challenges by n-3 FA supplementation.
- Recalculations from a report in Alzheimer's disease patients indicated a dose–response pattern between increments of serum n-3 FAs and cognitive improvement.
- Still, a Cochrane review (using three randomized control trials) concluded that n-3 FAs cannot provide any 6-month benefit in patients with mild/moderate Alzheimer's disease.