Deans' stroke musings

Changing stroke rehab and research worldwide now.Time is Brain!Just think of all the trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 493 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It's quite disgusting that this information is not available from every stroke association and doctors group.
My back ground story is here:http://oc1dean.blogspot.com/2010/11/my-background-story_8.html

Tuesday, April 18, 2017

Exosome mediated delivery of miR-124 promotes neurogenesis after ischemia

Followup needed to create a stroke protocol out of this.

Exosome mediated delivery of miR-124 promotes neurogenesis after ischemia

Title:
Exosome mediated delivery of miR-124 promotes neurogenesis after ischemia
Running title:
Exosomal delivery of miR-124 promotes neurogenesis
Authors:
Jialei Yang
a,b,1
, Xiufen Zhang
b,1
, Xiangjie Chen
c
, Lei Wang
a
*
, Guodong
Yang
b
*
Authors affiliations:
a
Department of Neurology, New Era Stroke Care and Re
search Institute, The General
Hospital of the PLA Rocket Force, 16 Xinjiekouwai A
venue, Beijing 100088, China.
b
Department of Biochemistry and Molecular Biology, S
chool of Basic Medicine, The
Fourth Military Medical University, 169 Changlexi R
oad, Xi’an, Shaanxi 710032,
China.
c
Department of Mathematics, Southeast University, Na
njing 211189, China.
1
These authors contribute equally to the work.
*Correspondence should be addressed to Dr. Guodong
Yang (yanggd@fmmu.edu.cn.)
and Dr. Lei Wang (hellowanglei068@163.com)
*Corresponding author:
Dr. Guodong Yang
Department of Biochemistry and Molecular Biology, S
chool of Basic Medicine,
Fourth Military Medical University, 169 Chang Le Xi
Road, Xi’an, Shaanxi 710032,
China.
Tel: +86-29-84774516
Fax: +86-29-84774937
Email: yanggd@fmmu.edu.cn.
Dr. Lei Wang
Department of Neurology, New Era Stroke Care and Re
search Institute, The Second
Artillery General Hospital, Chinese People’s Libera
tion Army, 16 Xinjiekouwai
Avenue, Beijing 100088, China.
Tel:+86-10-66343682
Email: hellowanglei068@163.com

Abstract
The intrinsic ability of neurogenesis after stroke has been proven weak, which results in insufficient repair of injury in the nerve system. Recent studies suggest multiple microRNAs (miRNAs) are involved in the neuroremodeling process. Targeted miRNAs delivery for amplification of neurogenesis is promising in promoting the prognosis after ischemia. Here we showed that modified exosomes, with rabies virus glycoprotein (RVG) fused to exosomal protein lysosome-associated membrane glycoprotein 2b (Lamp2b), could efficiently deliver miR-124 to the infarct site. Systemic administration of RVG-exosomes loaded with miR-124 promoted cortical neural progenitors to obtain neuronal identity and protect against ischemic injury by robust cortical neurogenesis. Our study suggests that RVG-exosomes can be utilized therapeutically for the targeted delivery of gene drugs to the brain, thus having great potential for clinical applications.

No comments:

Post a Comment