Cell-Based Therapy for Stroke

So very specifically, WHOM  is going to do the followup with human testing? Specific names only. Without specific names NOTHING WILL OCCUR. 

Stroke is so fucking easily solvable, create a strategy and run that strategy to completion.  But NO, we have fucking failures of stroke associations that couldn't get out of a paper bag with a pair of scissors AND a machete. That should get me a response from those presidents. But they will never contact me, too scared to talk to a stroke survivor who knows more than they do. With NO leadership and NO strategy stroke will never be solved. Which is why everyone in stroke needs to be fired.

Cell-Based Therapy for Stroke

Musing With Muse Cells

You Jeong Park

,

Kuniyasu Niizuma

,

Maxim Mokin

,

Mari Dezawa

,

Cesar V. Borlongan

Originally published19 Aug 2020https://doi.org/10.1161/STROKEAHA.120.030618Stroke. 2020;51:2854–2862

Abstract

Stem cell-based regenerative therapies may rescue the central nervous system following ischemic stroke. Mesenchymal stem cells exhibit promising regenerative capacity in in vitro studies but display little to no incorporation in host tissue after transplantation in in vivo models of stroke. Despite these limitations, clinical trials using mesenchymal stem cells have produced some functional benefits ascribed to their ability to modulate the host’s inflammatory response coupled with their robust safety profile. Regeneration of ischemic brain tissue using stem cells, however, remains elusive in humans. Multilineage-differentiating stress-enduring (Muse) cells are a distinct subset of mesenchymal stem cells found sporadically in connective tissue of nearly every organ. Since their discovery in 2010, these endogenous reparative stem cells have been investigated for their therapeutic potential against a variety of diseases, including acute myocardial infarction, stroke, chronic kidney disease, and liver disease. Preclinical studies have exemplified Muse cells’ unique ability mobilize, differentiate, and engraft into damaged host tissue. Intravenously transplanted Muse cells in mouse lacunar stroke models afforded functional recovery and long-term engraftment into the host neural network. This mini-review article highlights these biological properties that make Muse cells an exceptional candidate donor source for cell therapy in ischemic stroke. Elucidating the mechanism behind the therapeutic potential of Muse cells will undoubtedly help optimize stem cell therapy for stroke and advance the field of regenerative medicine.

Footnotes

For Sources of Funding and Disclosures. See page 2860.

Correspondence to: Cesar V. Borlongan, MA, PhD, Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL 33612. Email cborlong@usf.edu

 

This was with the Twitter feed. So ask your doctor when this is available.