Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Thursday, September 17, 2026

Astrocytic Gq pathway activation enhances the efficacy of rehabilitation after stroke

 You'll have to get your incompetent? doctor and hospital to get human testing going! But that won't occur, will it?

Astrocytic Gq pathway activation enhances the efficacy of rehabilitation after stroke


, , , , ,
a
Department of Molecular Neuroscience, Graduate School of Medicine, The University of Osaka, Osaka, 565-0871, Japan
b
Department of Orthopaedic Surgery, Graduate School of Medicine, The University of Osaka, Osaka, 565-0871, Japan
c
Department of Neuro-Medical Science, Graduate School of Medicine, The University of Osaka, Osaka, 565-0871, Japan
d
WPI Immunology Frontier Research Center, The University of Osaka, Osaka, 565-0871, Japan
e
Graduate School of Frontier Bioscience, The University of Osaka, Osaka, 565-0871, Japan

Highlights

  • •
    Peri-infarct astrocytes are selectively activated using chemogenetics.
  • •
    Astrocytic activation alone is insufficient for functional recovery.
  • •
    Astrocytic activation potentiates rehabilitation-induced motor recovery.

Abstract

Stroke is a leading cause of functional impairment. As rehabilitation has a limited effect, it is essential to advance future treatments and enhance the efficacy of rehabilitation. This study focused on the use of astrocytes to augment the efficacy of rehabilitation for strokes. It utilized chemogenetics to specifically activate astrocytes in the peri-infarct region of a mouse photothrombosis model. The mice were subjected to immunohistochemical analysis and behavioral tests to evaluate the effects of astrocytic Gq pathway activation after an induced stroke. The timing of astrocytic activation was separated from that of rehabilitative training. It was observed that chemogenetic astrocytic activation prior to rehabilitation significantly augmented the efficacy of the training and promoted functional motor recovery after the induced stroke. Consequently, a better understanding of this mechanism could be a significant step toward future therapeutic breakthroughs.
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