Deans' stroke musings: Tooth loss inhibits neurogenesis in the dentate gyrus of adult mice

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Thursday, October 9, 2014

Tooth loss inhibits neurogenesis in the dentate gyrus of adult mice

Just for grins, ask your doctor how badly your neurogenesis is affected by the teeth you've lost. What stroke protocol is your doctor using to get around that problem? Would that include removed wisdom teeth?
http://www.nrronline.org/article.asp?issn=1673-5374;year=2014;volume=9;issue=17;spage=1606;epage=1609;aulast=Su

Shaochen Su¹, Tao Qi², Baoli Su³, Huibin Gu³, Jianlin Wang¹, Lan Yang¹
¹ School of Life Sciences, Lanzhou University; Second Hospital, Lanzhou University, Lanzhou, Gansu Province, China
² First Hospital, Lanzhou University, Lanzhou, Gansu Province, China
³ Changzhou Institute of Mechatronic and Technology, Changzhou, Jiangsu Province, China

Date of Acceptance	30-Jul-2014
Date of Web Publication	4-Oct-2014

Correspondence Address:
Jianlin Wang
School of Life Sciences, Lanzhou University; Second Hospital, Lanzhou University, Lanzhou 730030, Gansu Province
China
Lan Yang
School of Life Sciences, Lanzhou University; Second Hospital, Lanzhou University, Lanzhou 730030, Gansu Province
China

DOI: 10.4103/1673-5374.141786

Abstract

Tooth loss has been shown to affect learning and memory in mice and increases the risk of Alzheimer's disease. The dentate gyrus is strongly associated with cognitive function. This study hypothesized that tooth loss affects neurons in the dentate gyrus. Adult male mice were randomly assigned to either the tooth loss group or normal control group. In the tooth loss group, the left maxillary and mandibular molars were extracted. Normal control mice did not receive any intervention. Immunofluorescence staining revealed that the density and absorbance of doublecortin- and neuronal nuclear antigen-positive cells were lower in the tooth loss group than in the normal control group. These data suggest that tooth loss may inhibit neurogenesis in the dentate gyrus of adult mice.

Keywords: nerve regeneration; neurogenesis; neurons; tooth loss; hippocampus; dentate gyrus; doublecortin; neuronal nuclear antigen; neural regeneration

How to cite this article:
Su S, Qi T, Su B, Gu H, Wang J, Yang L. Tooth loss inhibits neurogenesis in the dentate gyrus of adult mice. Neural Regen Res 2014;9:1606-9