In rats but it probably does mean that if you get an infection post-stroke you'll have to direct your doctor to give you the correct antibiotic. Once again, I bet this will not be followed up in human testing for 50 years because we have NO one running a stroke strategy. No one seems to give a shit about the trillions upon trillions of neurons dying every single minute worldwide. We're flushing vast amounts of intelligence down the tube because the intelligence in our stroke associations is non-existent.
http://www.ncbi.nlm.nih.gov/pubmed/26138122
Abstract
BACKGROUND AND PURPOSE:
Infections
are common after stroke and associated with worse outcome. Clinical
trials evaluating the benefit of prophylactic antibiotics have produced
mixed results. This study explores the possibility that antibiotics of
different classes may differentially affect stroke outcome.
METHODS:
Lewis
rats were subjected to transient cerebral ischemia (2 hours) and
survived for 1 month. The day after stroke they were randomized to
therapy with ceftiofur (a β-lactam antibiotic), enrofloxacin (a
fluoroquinolone antibiotic), or vehicle (as controls) and underwent the
equivalent of 7 days of treatment. Behavioral tests were performed
weekly until euthanization. In a subset of animals, histology was done.
RESULTS:
There
were no differences in outcomes at 24 hours or 1 week after stroke
among the different groups. At 1 month after stroke, however,
performance on the rotarod was worse in enrofloxacin-treated animals
when compared with control animals.
CONCLUSIONS:
Independent
of infection, the antibiotic enrofloxacin was associated with worse
stroke outcome. These data echo the clinical observations to date and
suggest that the secondary effects of antibiotics on stroke outcome
should be considered when treating infection in subjects with stroke.
The mechanism by which this antibiotic affects outcome needs to be
elucidated.
My stroke was caused by a rare bacterial infection called Whipple Disease. It took 2 weeks in the hospital after the stroke and about 60 doctors to diagnose and start 28 days of IV brain membrane penetrating antibiotics to kill the bacteria and stop the death cascade of neurons, but not before it killed a 2.4 cm x 4.0 cm area of the upper motor cortex leaving me w/ 100% hemiparesis of my non-dominant left side. No one explained that aspect to me. I figured it out after I found your blog. Thank you for doing this.
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