Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Sunday, August 9, 2015

Kidney Function Impairment Linked to Brain Disorders

Is your doctor checking this out post-stroke and treating it?
http://neurosciencenews.com/brain-blood-flow-kidney-function-2401/

A growing body of research suggests a link between kidney impairment and brain disorders.

Impaired kidney function may lead to decreased blood flow to the brain, and ultimately to the occurrence of stroke or dementia. The findings, which come from a study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN), suggest that maintaining optimal kidney health can provide benefits to the brain.

Stroke and dementia are more common in patients with chronic kidney disease than in individuals in the general population, but it’s unclear why. To investigate a potential kidney-brain link, M. Arfan Ikram, MD, PhD, Sanaz Sedaghat, MSc (Erasmus University Medical Center, in the Netherlands), and their colleagues examined information on 2645 participants in the population–based Rotterdam Study, looking at individuals’ kidney function and blood flow to the brain.

The investigators found that poor kidney function was strongly related to decreased blood flow to the brain, or hypoperfusion. Also, poor kidney function was linked to stroke and dementia most strongly in participants with hypoperfusion. These findings were independent from known cardiovascular risk factors.

This image shows the anterior surfaces of the kidneys.
The investigators found that poor kidney function was strongly related to decreased blood flow to the brain, or hypoperfusion. This image is for illustrative purposes only. Image credit: Henry Gray.

“Our findings provide a possible explanation linking kidney disease to brain disease,” said Dr. Ikram. “Also, given that kidney disease and hypoperfusion of the brain are both possibly reversible, there might be an opportunity to explore how improving these conditions can ultimately reduce one’s risk of developing brain disease.” The study also shows that the kidney-brain link is not confined to patients with chronic kidney disease, but extends to persons from the general population without overt disease.

Original Research: Abstract for “Kidney Function and Cerebral Blood Flow: The Rotterdam Study” by Sanaz Sedaghat, Meike W. Vernooij, Elizabeth Loehrer, Francesco U.S. Mattace-Raso, Albert Hofman, Aad van der Lugt, Oscar H. Franco, Abbas Dehghan, and M. Arfan Ikram in JASN. Published online August 6 2015 doi:10.1681/ASN.2014111118



Abstract

Kidney Function and Cerebral Blood Flow: The Rotterdam Study

CKD is linked with various brain disorders. Whereas brain integrity is dependent on cerebral perfusion, the association between kidney function and cerebral blood flow has yet to be determined. This study was performed in the framework of the population–based Rotterdam Study and included 2645 participants with mean age of 56.6 years (45% men). We used eGFR and albumin-to-creatinine ratio to assess kidney function and performed phase–contrast magnetic resonance imaging of basilar and carotid arteries to measure cerebral blood flow. Participants had an average (SD) eGFR of 86.3 (13.4) ml/min per 1.73 m2 and a median (interquartile range) albumin-to-creatinine ratio of 3.4 (2.2–6.1) mg/g. In age- and sex-adjusted models, a higher albumin-to-creatinine ratio was associated with lower cerebral blood flow level (difference in cerebral blood flow [milliliters per minute per 100 ml] per doubling of the albumin-to-creatinine ratio, −0.31; 95% confidence interval, −0.58 to −0.03). The association was not present after adjustment for cardiovascular risk factors (P=0.10). Each 1 SD lower eGFR was associated with 0.42 ml/min per 100 ml lower cerebral blood flow (95% confidence interval, 0.01 to 0.83) adjusted for cardiovascular risk factors. Thus, in this population-based study, we observed that lower eGFR is independently associated with lower cerebral blood flow.

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