Deans' stroke musings

Changing stroke rehab and research worldwide now.Time is Brain!Just think of all the trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 493 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It's quite disgusting that this information is not available from every stroke association and doctors group.
My back ground story is here:http://oc1dean.blogspot.com/2010/11/my-background-story_8.html

Thursday, January 5, 2017

Coffee intake, cardiovascular disease, and all-cause mortality: Observational and Mendelian randomization analyses in 95000-223000 individuals

Was this research from Nov. 2015 not enough to answer the question? That it had to be repeated? This is why we need some leadership and a strategy so we don't waste time and money on stuff we already know.

Moderate coffee drinking may be linked to reduced risk of death Nov. 2015

 The latest here:

Coffee intake, cardiovascular disease, and all-cause mortality: Observational and Mendelian randomization analyses in 95000-223000 individuals

International Journal of Epidemiology, 01/05/2017
The goal of this study were: first whether coffee consumption is connected with cardiovascular disease and all–cause mortality observationally; second, whether genetic variations previously connected with caffeine consumption are connected with coffee consumption; and third, whether the genetic variations are connected with cardiovascular disease and all–cause mortality. Observationally, coffee consumption was connected with the U–shaped lower risk of cardiovascular disease and all–cause mortality; however, genetically caffeine consumption was not connected with the risk of cardiovascular disease or all–cause mortality.

Methods

  • First, they utilized multivariable adjusted Cox proportional hazard regression models assessed with limited cubic splines to analyze the observational relationship in 95366 White Danes.
  • Second, they evaluated mean coffee consumption as per 5 genetic variations near the AHR (rs4410790; rs6968865) and CYP1A1/2 genes (rs2470893; rs2472297; rs2472299).
  • Third, they utilized sex– and age adjusted Cox proportional hazard regression models to inspect genetic relationship with cardiovascular disease and all–cause mortality in 112509 Danes.
  • At last, they utilized sex and age–adjusted logistic regression models to analyze genetic associations with ischaemic heart disease including the Cardiogram and C4D consortia in a total of up to 223414 individuals.
  • They applied comparable examinations to ApoE genotypes connected with plasma cholesterol levels, as a positive control.

Results

  • In observational investigations, they found U–shaped relationship between coffee consumption and cardiovascular disease and all–cause mortality; lowest risks were found in individuals with medium coffee consumption.
  • Caffeine consumption allele score (rs4410790 + rs2470893) was connected with a 42% higher coffee consumption.
  • Hazard ratios per caffeine consumption allele were 1.02 (95% confidence interval: 1.00–1.03) for ischaemic heart disease, 1.02 (0.99–1.02) for ischaemic stroke, 1.02 (1.00–1.03) for ischaemic vascular disease, 1.02 (0.99–1.06) for cardiovascular mortality and 1.01 (0.99–1.03) for all–cause mortality.
  • Including international consortia, odds ratios per caffeine consumption allele for ischaemic heart disease were 1.00 (0.98–1.02) for rs4410790, 1.01 (0.99–1.03) for rs6968865, 1.02 (1.00–1.04) for rs2470893, 1.02 (1.00–1.04) for rs2472297 and 1.03 (0.99–1.06) for rs2472299.
  • Conversely, 5% lower cholesterol level caused by ApoE genotype had a corresponding odds ratio for ischaemic heart disease of 0.93 (0.89–0.97).
Go to PubMed Go to Abstract Print Article Summary Cat 2 CME Report

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