https://www.mdlinx.com/family-medicine/medical-news-article/2016/12/13/coffee-chlorogenic-acid-vascular-phenolics-flow-mediated-dilatation-fmd-/6965864/?
Mills
CE, et al. – The researchers performed this work to inspect the effect
of coffee intake rich in chlorogenic acid on human vascular function and
whether chlorogenic acids (CGAs) are involved in potential effects. The
results of this study reveal that coffee intake acutely enhances human
vascular function, an effect, in part, mediated by 5–CQA and its
physiological metabolites.
Methods
- For the purpose of this study, two acute randomized, controlled, cross-over human intervention trials were conducted.
- The effect of coffee intake, matched for caffeine but differing in CGA content (89, and 310 mg) on flow-mediated dilation (FMD) was evaluated in 15 healthy male subjects.
- In a second intervention trial conducted with 24 healthy male subjects, the effect of pure 5-caffeoylquinic acid (5-CQA), the main CGA in coffee (5-CQA; 450 mg and 900 mg) on FMD was also examined.
Results
- Researchers observed a bi-phasic FMD response after low and high polyphenol, (89 mg and 310 mg CGA) intake, with increments at 1 (1.10 ± 0.43% and 1.34 ± 0.62%, respectively) and 5 (0.79% ± 0.32 and 1.52% ± 0.40, respectively) hours post coffee consumption.
- The results of this study showed that FMD responses to coffee intake was closely paralleled by the appearance of CGA metabolites in plasma, notably 3-, 4- and 5-CQA and ferulic-4'-O-sulfate at 1 h and isoferulic-4'-O-glucuronide and ferulic-4'-O-sulfate at 5 h.
- The findings demonstrated that intervention with purified 5-CQA (450 mg) also led to an improvement in FMD response relative to control (0.75 ± 1.31% at 1 h post intervention, p = 0.06) and concomitant appearance of plasma metabolites.
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