http://journals.lww.com/journaloftraumanursing/Abstract/2017/01000/Omega_3_Fatty_Acid_Supplementation_and_Warfarin__.4.aspx
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Journal of Trauma Nursing:
doi: 10.1097/JTN.0000000000000256
Case Study
Omega-3 Fatty Acid Supplementation and Warfarin: A Lethal Combination in Traumatic Brain Injury
Gross, Brian W. BS; Gillio, Maria BS; Rinehart, Cole D. BS; Lynch, Caitlin A. BS; Rogers, Frederick B. MD, MS, FACS
Polyunsaturated fatty acids such as omega-3
eicosapentaenoic acid and omega-6 docosahexaenoic acid, found in
over-the-counter fish oil supplements, are often consumed for their
beneficial, prophylactic, anti-inflammatory effects. Although the
mechanisms of action are not fully known, a diet rich in polyunsaturated
fats may reduce the risk of hyperlipidemia, atherosclerosis, high
low-density lipoprotein cholesterol levels, hypertension, and
inflammatory diseases. Masked by its many benefits, the risks of omega-3
fatty acid supplementation are often underappreciated, particularly its
ability to inhibit platelet aggregation and promote bleeding in
patients taking anticoagulant medications. The following details the
clinical case of an elderly patient taking warfarin and fish oil
supplementation whose warfarin-induced coagulopathy could not be
reversed after suffering blunt head trauma.
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