Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Tuesday, November 14, 2017

Effect of glial cells on remyelination after spinal cord injury

Do we need this after a stroke? Have we demyelinated neurons in the brain? What does your doctor know about this and what is the protocol to fix it?  Scream at your doctor if you have to get her attention about actually fixing you up to 100% recovery. 

Effect of glial cells on remyelination after spinal cord injury





1 Department of Neurosurgery, First Hospital of Jilin University, Changchun, Jilin Province, China
2 Department of Hepatobiliary and Pancreas Surgery, First Hospital of Jilin University, Changchun, Jilin Province, China
3 Hand & Foot Surgery and Reparative & Reconstruction Surgery Center, Second Hospital of Jilin University, Changchun, Jilin Province, China
4 Department of Emergency, First Hospital of Jilin University, Changchun, Jilin Province, China
5 Department of Cardiology, First Hospital of Jilin University, Changchun, Jilin Province, China
6 Department of Surgery, School of Medicine, University of Louisville, Louisville, KY, USA
7 Department of Orthopedics, First Hospital of Jilin University, Changchun, Jilin Province, China

Date of Acceptance14-Sep-2017
Date of Web Publication10-Nov-2017
Correspondence Address:
Bin Liu
Department of Cardiology, First Hospital of Jilin University, Changchun, Jilin Province
China
Yuan-yi Wang
Department of Orthopedics, First Hospital of Jilin University, Changchun, Jilin Province
China
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Source of Support: This work was supported by the National Natural Science Foundation of China, No. 81601957., Conflict of Interest: None



DOI: 10.4103/1673-5374.217354
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  Abstract
Remyelination plays a key role in functional recovery of axons after spinal cord injury. Glial cells are the most abundant cells in the central nervous system. When spinal cord injury occurs, many glial cells at the lesion site are immediately activated, and different cells differentially affect inflammatory reactions after injury. In this review, we aim to discuss the core role of oligodendrocyte precursor cells and crosstalk with the rest of glia and their subcategories in the remyelination process. Activated astrocytes influence proliferation, differentiation, and maturation of oligodendrocyte precursor cells, while activated microglia alter remyelination by regulating the inflammatory reaction after spinal cord injury. Understanding the interaction between oligodendrocyte precursor cells and the rest of glia is necessary when designing a therapeutic plan of remyelination after spinal cord injury.

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