https://consultqd.clevelandclinic.org/2017/10/first-trial-of-dbs-for-stroke-recovery-initial-patients-functional-progress-continues-through-5-months/?utm_campaign=qd%20tweets&utm_medium=social&utm_source=twitter&utm_content=171018%20stroke%20recovery&cvosrc=social%20network.twitter.qd%20tweets&cvo_creative=171018%20stroke%20recovery
A trial status update and overview of investigational aspects
Essentials of the trial
Our trial is examining a novel strategy — stimulation of the dentatothalamocortical pathway to enhance excitability and plasticity across spared cerebral cortical regions — with the aim of promoting recovery of motor function following stroke. The primary hypothesis is that by applying DBS to the connections between the cerebellum and cerebral cortex, we can facilitate the plasticity that occurs in the surviving cortical regions around the stroke and thereby promote recovery of function beyond what rehabilitative therapy alone can accomplish.For this initial trial, we plan to enroll 12 patients who, despite traditional rehabilitative therapy, have persistent, severe residual hemiparesis from an ischemic stroke 12 to 36 months earlier. In addition to the patient reported here, a second patient has undergone DBS electrode implantation but hasn’t completed enough subsequent therapy for results to be reported.
The study is being conducted solely at Cleveland Clinic with funding support from the National Institutes of Health’s BRAIN initiative.
Initial treatment protocol — and first patient’s response
The trial’s initial protocol began as follows:- One month of twice-weekly rehabilitative (physical plus occupational) therapy to establish baseline function
- Surgery to implant the DBS electrode and battery
- Four-week resting period at home to recover from surgery
- Eight weeks of therapy without the DBS device turned on, to establish a new functional baseline
- Four weeks of programming the DBS device with the aid of transcranial magnetic stimulation
- Four months of therapy with the DBS device turned on continuously
Continuing improvement prompts protocol revision
The initial trial protocol called for a slow weaning from stimulation over the course of a month after completion of four months of concurrent DBS and physical therapy. However, continued progress by the first patient across even the fourth month of stimulation prompted us to obtain FDA approval to revise the protocol and extend therapy. Concurrent DBS and physical therapy will now continue for several additional months to afford the patient the opportunity for additional improvement, with stimulation weaned after nine months of treatment or when the patient’s motor improvement appears to have plateaued (whichever comes first).Additional aspects of our investigation
In addition to the above functional outcomes that are the centerpiece of this trial, we are conducting many other investigations to better understand the relevant anatomy and refine the DBS technique used in this novel setting of stroke recovery. These investigations include the following:7T magnetic resonance imaging (MRI). Each trial participant undergoes 7T MRI prior to surgery to allow optimal visualization of target brain structures. Our team’s engineers use these images to develop patient-specific models of the pathways that we are attempting to modulate in order to achieve the therapeutic goal. These 7T images and the resulting models will help create a guidebook to elucidate the relevant anatomy for neuromodulation for stroke rehabilitation moving forward. While postoperative 7T MRI evaluation would be valuable as well, the DBS device used is currently incompatible with MRI.
Serial positron emission tomography (PET). All patients undergo a series of four FDG-PET imaging studies — at enrollment, after DBS electrode implantation, during DBS treatment and a month after stimulation is turned off. These studies will test our hypothesis that metabolic activity along the brain pathway being targeted with DBS will increase in conjunction with any observed therapeutic improvements. Below is a baseline FDG-PET image from the trial’s first patient showing a right hemisphere stroke (Figure 2).
We are supplementing our initial 7T imaging guidance with intraoperative SSEP and EEG recordings at the time of DBS lead placement. These techniques may allow us to determine which electrical contacts along the octopolar lead are showing greater representation of motor-related neural activity and to assess changes in activity in response to acute stimulation in different areas. Given that neuromodulation for stroke rehabilitation — in contrast to movement disorders — does not allow immediate motor feedback once stimulation is started, this type of intraoperative testing can be invaluable in helping to determine which contacts to use for chronic therapy.
Transcranial magnetic stimulation (TMS) to assess cortical changes. Our team is using TMS as part of the acute programming sessions to assess whether DBS is enhancing excitability across the areas of cortex where we hope to achieve functional change. Additionally, TMS is being used to map the representation of motor activity for different regions of the body across those same spared cortical regions in order to identify whether any functional reorganization of the cortex is being achieved in response to therapy.
On the horizon
We also plan to introduce several additional assessments for trial participants going forward, including:- Non-motor testing by a neuropsychologist to ensure there is no disruption of cognitive processes involving the stimulated brain region
- Use of a robotic device on which patients perform video game-like tasks to assess reaction and movement time, jerkiness of movement and similar performance measures
Clearly, many questions remain, but we are encouraged by the positive results so far in our trial’s initial patient. We look forward to learning much more as this study continues.
Dr. Machado is a neurosurgeon and Chairman of Cleveland Clinic’s Neurological Institute.
Dr. Baker is a neuroscientist in the Department of Neurosciences in Cleveland Clinic’s Lerner Research Institute.
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