Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Saturday, April 4, 2020

Electronic cigarette exposure disrupts blood-brain barrier integrity and promotes neuroinflammation

 How is your doctor having your nicotine delivered? 

So I guess I'll have to do patches for my nicotine needs post stroke.

Too bad the nicotine gum got cancelled.

Nicotine Holds Promise for Stronger Stroke Recovery

 

Nicotine Patch Appears To Help Mild Cognitive Loss

 

Can nicotine protect the aging brain?

This Legal Drug Could Protect Brain From Ageing - Nicotine

 

 

I'm going to do the nicotine patches for my next stroke even though I have no clue on dosage.  Don't listen to me with no medical training. Is your doctor trained in the latest research? Say the last 20 years?

The latest here:

Electronic cigarette exposure disrupts blood-brain barrier integrity and promotes neuroinflammation

AleciaSeligaaMalikaWinfieldaSachinGajghateaNancyReichenbachaXiangYucSlavaRomabAmoghaTennetiaDanaMayaBrian D.GregorycYuriPersidskyab


Highlights

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Electronic cigarettes reduce expression of Occludin in limbic brain regions.
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TNF-induced leukocyte adhesion to brain endothelium is worsened by electronic cigarettes.
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Nicotine-free electronic cigarettes worsen novel object recognition performance.

Abstract

Electronic cigarette (e-cigarette) use has grown substantially since inception, particularly among adolescents and combustible tobacco users. Several cigarette smoke constituents with known neurovascular effect are present in e-cigarette liquids or formed during the vapor generation. The present study establishes inhaled models of cigarette and e-cigarette use with normalized nicotine delivery, then characterizes the impact on blood-brain barrier function. Sequencing of microvessel RNA following exposure revealed downregulation of several genes with critical roles in BBB function. Reduced protein expression of Occludin and Glut1 is also observed at the tight junction in all groups following exposure. Pro-inflammatory changes in leukocyte-endothelial cell interaction are also noted, and mice exposed to nicotine-free e-cigarettes have impaired novel object recognition performance. On this basis, it is concluded that long term e-cigarette use may adversely impact neurovascular health. The observed effects are noted to be partly independent of nicotine content and nicotine may even serve to moderate the effects of non-nicotinic components on the blood-brain barrier.

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