Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there. Did your doctor somehow miss the recovery protocol that Pedro Bach-y-Rita used to recover fully back in 1958 with only a partial brain?

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Monday, April 2, 2018

Neuroscience reveals 4 rituals that will make you happy

Is your doctor suggesting any of these? Or is s/he doing absolutely NOTHING?

Neuroscience reveals 4 rituals that will make you happy

1. The most important question to ask when you feel down
What am I grateful for?
2. Label negative feelings
3. Make that decision
4. Touch people 

Details at link.

For Many Strokes, There’s an Effective Treatment. Why Aren’t Some Doctors Offering It?

Sorry, but tPA is a failure. Only 12% full recovery with its use.
Comments are closed so no longer can correct misinformation presented. 

For Many Strokes, There’s an Effective Treatment. Why Aren’t Some Doctors Offering It?

Are you taking too much anti-inflammatory medication?

NSAIDs? Aspirin?

Are you taking too much anti-inflammatory medication?

Smartphone App Measures Parkinson's Severity

This should be so easy to modify this for stroke but our fucking failures of stroke associations will DO NOTHING. Your doctor will DO NOTHING . Your stroke hospital will DO NOTHING.  You're screwed. 
https://www.medpagetoday.com/neurology/parkinsonsdisease/71995
  • by
Contributing Writer, MedPage Today
A smartphone application can provide objective measures of Parkinson's disease (PD) severity to help manage symptoms more effectively, reported researchers from Johns Hopkins University and the University of Rochester.
With the HopkinsPD app, Parkinson's disease patients can report objective, real-time movements and responses to medication to complement standard measures. "Patients can use their mobile phones to complete a few simple tasks which the proposed method turns into an objective score," explained Suchi Saria, PhD, of Johns Hopkins' Department of Computer Science. "This score, when plotted over time, provides a lens into the patient's Parkinson symptom profile and how it's varying over time."

In an observational study published online in JAMA Neurology, Saria and colleagues assessed individuals with PD who remotely completed five tasks -- voice, finger tapping, gait, balance, and reaction time -- on the app. A novel machine-learning approach was used that objectively weighed features derived from each smartphone activity -- stride length from the gait activity, for example -- and generated a mobile Parkinson disease score (mPDS) with a scale from 0 to 100.
The mobile score captured intraday symptom fluctuations, correlated strongly with current standard rating scales, and detected responses to dopaminergic therapy.
"Patients with Parkinson's disease show large fluctuations in disease severity from hour to hour," Saria noted. "But right now, we don't have ways to measure daily symptom fluctuations." Currently, many patients keep a motor diary and record when they experience good symptom control or complications like dyskinesia; these diaries are used to adjust medication doses.
"If we could measure daily symptom fluctuations and long-term trends in symptom severity objectively, it would be possible to titrate medications more precisely based on an individual's symptom profile," she said. "If the patient is not being responsive, we could add or change the mode of delivery or add medications to improve efficacy of levodopa."
The researchers derived the mPDS from 6,148 smartphone activity assessments collected from 129 individuals. Gait contributed 33% to the total score, balance 23%, finger-tapping 23%, voice 17%, and reaction time 3%.

The analysis showed that the mPDS correlated well with the Movement Disorder Society Unified Parkinson Disease's Rating Scale total (correlation coefficient r=0.81; P*lt;0.001) and part III only (r=0.88; P<0.001), the Timed Up and Go assessment (r=0.72; P=0.002), and the Hoehn and Yahr stage (r=0.91; P<0.001). The measure detected symptom fluctuations with a mean intraday change of 13.9 points, and improved by 16.3 points when patients received dopaminergic therapy.
The mPDS needs to be validated further in a larger sample, the researchers noted. And while this approach was applied to a smartphone application, it could be extended to wearable sensors or other devices, Saria said.
The study was funded in part by the Michael J. Fox Foundation and the National Institute of Neurological Disorders and Stroke.
The authors reported having no conflicts of interest.
last updated
  • Primary Source
JAMA Neurology
Source Reference: Zhan A, et al "Using smartphones and machine learning to quantify Parkinson disease severity: The mobile Parkinson disease score" JAMA Neurology 2018; DOI:10.1001/jamaneurol.2018.0809.

What Happens When the Patient Becomes the Boss?

For YOUR stroke recovery YOU are going to have to become the boss because your doctor is doing  nothing in the first week by stopping the 5 causes of the neuronal cascade of death.
My 31 ideas on hyperacute therapy I'm going to insist my doctor give me during the first week.
even without further research or real clinical trials. I will take the chance that more benefits accrue than danger by using these. But run them by your doctor. No knowledge of any of them and you need to fire that doctor immediately, practicing medicine with no knowledge. 

Or these 177 hyperacute therapies that need more research.    
But I'm not medically trained so do not do anything with this information.  

What Happens When the Patient Becomes the Boss?

By Alexandra Sifferlin
March 20, 2018

TIME Health
For more, visit TIME Health.
LAGUNA NIGUEL, Calif.—Patients today have access to tools that allow them to know much more about their personal health than ever before—for better or for worse. Whether it’s the ability to look up clinical trials and new research or use wearable devices that track everything from steps to sleep quality, men and women can gather more information and bring more informed questions to their doctor. But is the medical community ready for it?
At Fortune magazine’s Brainstorm Health conference, medical leaders talked about how patients can become more empowered, and the obstacles they still face. “I would say the patient is not yet in the driver’s seat, but should be in the driver’s seat,” says Dr. Valerie Montgomery Rice, the president and dean, of Morehouse School of Medicine. “Right now the disease is in the driver’s seat.”
Part of the reason for this, Rice says, is that doctors are not necessarily as well educated in the technology aspects of their job, and the ability to use multiple data sources to make decisions—even if patients are ready for that kind of care. To improve the modern doctor-patient relationship, more may need to be done to educate physicians. Rice says Morehouse is working to make sure physicians are exposed to technology much earlier, starting in medical school. Students right way learn how to use electronic medical records (which Rice says are in desperate need of an update) as well as how to embrace technology in their jobs—from basic electronics like laptops to social media. “We need them to be comfortable using technology,” she says.

Even medical professionals have learned about the need to take medical care into their own hands as patients. Dr. Eric Topol, the founder and director of Scripps Translational Science Institute, told the audience about the “nightmare-ish course” that happened to him in the following his knee surgery when his physician couldn’t figure out what was wrong (his wife ultimately diagnosed him after spending some time combing the Internet for answers).
But there’s also the benefit of having more control. Christi Shaw, the president of Lilly Bio-Medicines, talked about becoming the caregiver for her sister with multiple myeloma, a cancer that forms in plasma cells. Though doctors told Shaw they were out of treatment options for her sister, Shaw contacted other medical experts and learned about a study of an un-approved drug in that could work. Her sister’s doctor was open to trying it, and it ultimately reduced her sister’s cancer significantly within one month, according to Shaw. Without her own research and persistence, her sister’s medical team wouldn’t have known about the drug in the first place.
“The science is exploding and it’s coming so fast at us, and we need to figure out how to harness it,” Shaw said.
Not all physicians may be ready for patients to take more ownership of their health and treatment plans, but the panelists agreed that medicine is moving in the direction of more educated and empowered patients. One way patients can improve their own treatment experiences, Shaw suggests, is by studying up before their doctors appointments and bringing their physicians specific questions to discuss during short appointments. One day, they may even be able to present doctors with data from wearable devices like fitness trackers and smartwatches, too.
“We need to embrace and cultivate that [people] are taking more charge of their care,” said Topol.

Gene Therapy May Help Brain Heal From Stroke, Other Injuries

Astrocytes are very important to our recovery, 74 posts on them already. What will your doctor be doing with this information to get you to 100% recovery?  ANYTHING AT ALL? Or are your doctors and stroke hospital sitting on their asses waiting for SOMEONE ELSE TO SOLVE THE PROBLEM?
https://www.rdmag.com/news/2018/03/gene-therapy-may-help-brain-heal-stroke-other-injuries?
Scientists have found a genetic trigger that may improve the brain's ability to heal from a range of debilitating conditions, from strokes to concussions and spinal cord injuries.
A new study in mice from UT Southwestern's O'Donnell Brain Institute shows that turning on a gene inside cells called astrocytes results in a smaller scar and - potentially - a more effective recovery from injury.
The research examined spinal injuries but likely has implications for treating a number of brain conditions through gene therapy targeting astrocytes, said Dr. Mark Goldberg, Chairman of Neurology & Neurotherapeutics at UT Southwestern.
"We've known that astrocytes can help the brain and spinal cord recover from injury, but we didn't fully understand the trigger that activates these cells," Dr. Goldberg said. "Now we'll be able to look at whether turning on the switch we identified can help in the healing process."
The study published in Cell Reports found that the LZK gene of astrocytes can be turned on to prompt a recovery response called astrogliosis, in which these star-shaped cells proliferate around injured neurons and form a scar.
Scientists deleted the LZK gene in astrocytes of one group of injured mice, which decreased the cells' injury response and resulted in a larger wound on the spinal cord. They overexpressed the gene in other injured mice, which stimulated the cells' injury response and resulted in a smaller scar. Overexpressing the gene in uninjured mice also activated the astrocytes, confirming LZK as a trigger for astrogliosis.
Dr. Goldberg said a smaller scar likely aids the healing process by isolating the injured neurons, similar to how isolating a spreading infection can improve recovery. "But we don't know under what circumstances this hypothesis is true because until now we didn't have an easy way to turn the astrocyte reactivity on and off," he said.
Further study is needed to analyze whether a compact scar tissue indeed improves recovery and how this process affects the neurons' ability to reform connections with each other.
Dr. Goldberg's lab will conduct more research to examine the effects of astrogliosis in stroke and spinal cord injuries. The researchers will determine whether turning up LZK in mice in advance of an injury affects its severity. They will then measure how the formation of the compact scar helps or hinders recovery.
"It has been a big mystery whether increasing astrocyte reactivity would be beneficial," said Dr. Meifan Amy Chen, the study's lead author and Instructor of Neurology at the Peter O'Donnell Jr. Brain Institute. "The discovery of LZK as an on switch now offers a molecular tool to answer this question."

Modified Fatigue Impact Scale

This is for multiple sclerosis but since we seem to have nothing for stroke ask your doctor to objectively diagnose your fatigue and give SPECIFIC protocols to CURE that fatigue.  I got the lazy, exercise more, even though I had the cardiovascular fitness of an athlete, which my doctors never tested for.

Modified Fatigue Impact Scale (MFIS) : National Multiple Sclerosis ...

The Common Painkiller That Prevents Alzheimer’s Disease

The previous post on this did not mention the diet needed.
Not to be done for 50 years when all the interactions are known. You likely are taking aspirin already. Ask your doctor what SPECIFIC interventions you need to do to prevent Alzheimers.

Can You Take Aspirin and Ibuprofen Together? - Healthline

A dangerous combination. Both aspirin and ibuprofen belong to a drug class called nonsteroidal anti-inflammatory drugs (NSAIDs). They have similar side effects, and taking them together increases your risk of these side effects. Aspirin and ibuprofen can cause stomach bleeding, especially if you take too much.


The Common Painkiller That Prevents Alzheimer’s Disease

A simple daily regimen of the common painkiller ibuprofen along with dietary adjustments could prevent the onset of Alzheimer’s disease, new research concludes.
Ibuprofen is a widely available nonsteroidal anti-inflammatory that does not require a prescription.

The drug, along with adopting the Mediterranean diet and a healthy intake of antioxidants, could stop the disease in its tracks.
Until recently the problem has been identifying the disease early enough to take action.
Alzheimer’s is thought to begin around 10 years before any cognitive symptoms are noticeable.
The author of the new research, Dr Patrick McGeer (and colleagues), have developed a simple saliva test that can predict the onset of Alzheimer’s.
Dr Patrick McGeer, study co-author, explained:
“Knowing that the prevalence of clinical Alzheimer’s Disease commences at age 65, we recommend that people get tested ten years before, at age 55, when the onset of Alzheimer’s would typically begin.
If they exhibit elevated Abeta 42 levels then, that is the time to begin taking daily ibuprofen to ward off the disease.
Abeta 42 refers to a protein secreted in the saliva that is elevated in people at risk of developing Alzheimer’s.
It could provide the vital clue to start treatment early, Dr McGeer said:
“Unfortunately, most clinical trials to date have focused on patients whose cognitive deficits are already mild to severe, and when the therapeutic opportunities in this late stage of the disease are minimal.
Consequently, every therapeutic trial has failed to arrest the disease’s progression.
Our discovery is a game changer.
We now have a simple test that can indicate if a person is fated to develop Alzheimer’s disease long before it begins to develop. Individuals can prevent that from happening through a simple solution that requires no prescription or visit to a doctor.
This is a true breakthrough since it points in a direction where AD can eventually be eliminated.”

Rapid, Portable Stroke Detection Device is 92 Percent Accurate

So fucking what? Is it better than these other fast diagnosis tools? Only 92%, which means YOU had better have full blown classic stroke symptoms. You can tell how incompetent your hospital is by whether there are testing these OR even know about them.

Hats off to Helmet of Hope - stroke diagnosis in 30 seconds


 


Microwave Imaging for Brain Stroke Detection and Monitoring using High Performance Computing in 94 seconds


 


New Device Quickly Assesses Brain Bleeding in Head Injuries - 5-10 minutes


Noninvasive Cerebral Oximetry May Help Detect LAO Stroke - 1-2 minutes

  The latest here:

  Rapid, Portable Stroke Detection Device is 92 Percent Accurate

by Medical University of South Carolina

A new device worn like a visor can detect emergent large-vessel occlusion in patients with suspected stroke with 92 percent accuracy, report clinical investigators at the Medical University of South Carolina (MUSC), Mount Sinai, the University of Tennessee Health Sciences Center and elsewhere in an article published online on March 6, 2018, in the Journal of Neurointerventional Surgery. Patients with large-vessel occlusions can then be routed to a Comprehensive Stroke Center with endovascular capabilities. In contrast, a standard physical examination achieved only 40 to 89 percent accuracy in identifying patients with large-vessel occlusion who could benefit from endovascular therapy.

The volumetric impedance phase shift spectroscopy (VIPS) device (Cerebrotech VisorTM, Cerebrotech Medical Systems, Pleasanton, CA) works by sending low-energy radio waves through the brain that change frequency when passing through fluids. Such waves are reflected back through the brain and then detected by the device. When a patient is having a severe stroke, the brain's fluids will change, producing an asymmetry in the radio waves detected by the VIPS device. The greater the asymmetry, the more severe the stroke.

Endovascular therapy within 24 hours is the standard of care for emergent large-vessel occlusion, but the chance of achieving a good outcome decreases by approximately 20 percent for each hour that passes before treatment.

The researchers hope that the device will save valuable time — especially important in stroke where time is brain — when it is deployed with emergency medical personnel in the field. This is because the accuracy of the device simplifies the decision made by emergency personnel about where to take patients first, according to Raymond D. Turner, M.D., professor of neurosurgery and chief of the Neuroscience Integrated Center of Clinical Excellence at MUSC. Turner served as principal investigator for MUSC in the VIPS for the Non-Invasive Detection of Hemispheric Bioimpedance Asymmetry in Severe Brain Pathology (VITAL) study reported in the article.

"Transfer between hospitals takes a lot of time," said Turner. "If we can give the information to emergency personnel out in the field that this is a large-vessel occlusion, that should change their thought process in triage as to which hospital they go to."

In the study, the VIPS device was deployed with emergency medical personnel in regions served by five Comprehensive Stroke Centers equipped with the endovascular capabilities to treat large-vessel occlusions that underlie severe stroke. Their goal was to use the device to accurately identify severe stroke and then compare the results to established physical examination methods(totally wrong comparison points, it should be these other fast tools, which means once again we need followup research) practiced by emergency personnel such as the Prehospital Acute Stroke Severity Scale.

Both healthy participants and patients with suspected stroke were evaluated by emergency personnel using the VIPS device. Three readings were taken and averaged — a process that takes about 30 seconds. Patients were also later evaluated by neurologists who provided definitive diagnoses using neuroimaging.

Compared to the neurologists' diagnoses, the device displayed 92 percent specificity — the ability to detect the difference between patients with severe stroke and those with other conditions such as mild stroke or healthy participants with no brain pathology. This places the VIPS device above standard physical examination tools used by emergency personnel that display specificity scores between 40 and 89 percent.

The VIPS device is made by Cerebrotech Medical Systems, which paid consultants to analyze the neuroimaging data independently. The neuroimaging data was needed to teach the VIPS device which radio waves were indicative of stroke. Yet the consultants did not have access to the VIPS radio wave data during their review of the images, thereby eliminating the potential of the consultants to choose data that might artificially inflate the device's accuracy. It is also not clear how the device would work for patients with cranial implants, as metal interferes with the device's operating radio frequencies.

The device's success may be found in its ability to give emergency personnel a clear answer as to whether a patient is experiencing a severe stroke. The VIPS device requires very little training to operate compared to that required to learn standard emergency examination skills, thereby reducing the possibility of human error during emergency diagnosis.

In their next steps, the researchers are undertaking the VITAL 2.0 study to determine if the VIPS device can use complex machine learning algorithms to teach itself how to discriminate between minor and severe stroke without the help of neurologists. If so, the VIPS device could have widespread clinical implications, helping emergency personnel decide whether to take a patient to a comprehensive stroke center or a primary stroke center for treatment.

Turner likens the use of the VIPS device in detecting severe stroke to the use of electrocardiography (ECG) to definitively detect acute myocardial infarction. He predicts that the device has the potential to be used widely by emergency personnel but also to appear in other public spaces. "This could potentially be something like a defibrillator," said Turner. "You can find out if a patient is having a stroke, just like you can put a defibrillator on a patient to see if they're having a heart attack."

Pilot Randomized Controlled Trial of the GO Game Intervention on Cognitive Function

The rules of the game are quite simple to learn but learning the strategy to win is incredibly hard. I learned in my mid 20s and never became any good at it. Their measurement of results is way too simplistic. It is like learning the rules of checkers but never keeping track of wins and losses.  
http://journals.sagepub.com/doi/abs/10.1177/1533317517753362
This study investigated the effects of an intervention using the game “GO” on cognitive function in nursing home residents and evaluated the acquisition of GO according to each stage of dementia. Participants were randomly assigned to either the GO intervention group or a control group, and the intervention was performed once weekly for 15 weeks. Cognitive tests were conducted before and after intervention, and 17 participants were included in the final analysis. Analysis of covariance demonstrated that in the intervention group, the digit span total score significantly improved and the digit span backward score was maintained, whereas these scores decreased in the control group. All participants, including those who had moderate dementia, acquired the rules of the game, and participants with mild cognitive impairment and mild dementia could play the game successfully. This study indicates that GO might improve the cognitive function of residents living in nursing homes.