http://www.neurology.org/content/early/2015/03/27/WNL.0000000000001525.short?rss=1
- Lewis B. Morgenstern, MD,
- Darin B. Zahuranec, MD, MS,
- Brisa N. Sánchez, PhD,
- Kyra J. Becker, MD,
- Madeleine Geraghty, MD,
- Rebecca Hughes, BA,
- Gregory Norris, MD and
- J. Claude Hemphill III, MD, MAS
- Correspondence to Dr. Morgenstern: lmorgens@umich.edu
-
10.1212/WNL.0000000000001525Neurology
- Abstract
- Full Text (PDF)
- Also available:
- Data Supplement
Abstract
Objective: This
study tested the hypothesis that patients without placement of new
do-not-resuscitate (DNR) orders during the first
5 days after intracerebral hemorrhage (ICH) have
lower 30-day mortality than predicted by the ICH Score without an
increase
in severe disability at 90 days.
Methods: This was a
prospective, multicenter, observational cohort study at 4 academic
medical centers and one community hospital.
Adults (18 years or older) with nontraumatic
spontaneous ICH, Glasgow Coma Scale score of 12 or less, who did not
have preexisting
DNR orders were included.
Results: One hundred nine subjects were enrolled. Mean age was 62 years; median Glasgow Coma Scale score was 7, and mean hematoma
volume was 39 cm3. Based on ICH Score
prediction, the expected overall 30-day mortality rate was 50%.
Observed mortality was substantially
lower at 20.2%, absolute average difference
29.8% (95% confidence interval: 21.5%–37.7%). At 90 days, 27.1% had
died, 21.5%
had a modified Rankin Scale score = 5 (severe
disability). A good outcome (modified Rankin Scale score 0–3) was
achieved by
29.9% and an additional 21.5% fell into the
moderately severe disability range (modified Rankin Scale score = 4).
Conclusions:
Avoidance of early DNR orders along with guideline concordant ICH care
results in substantially lower mortality than predicted.
The observed functional outcomes in this study
provide clinicians and families with data to determine the appropriate
goals
of treatment based on patients' wishes.
No comments:
Post a Comment